Rifaximin (80621-81-4),Rifaximin (80621-81-4) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Rifaximin
CAS No.:
80621-81-4
Molecular Structure:
Formula:
C₄₃H₅₁N₃O₁₁
Molecular Weight:
785.88
Deleted CAS:
88747-56-2
Synonyms:
L 105;L 105(ansamacrolide antibiotic);L 105SV;Rifamycin L 105;Rifamycin L 105SV;Xifaxan;refaximin;
Density:
1.366 g/cm³
Melting Point:
200-205 °C(dec)
Appearance:
Red-orange crystalline powder

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Chemistry

Structure of Rifaximin (CAS NO.80621-81-4):

Empirical Formula: C₄₃H₅₁N₃O₁₁
Molecular Weight: 785.8785
Index of Refraction: 1.634
Molar Refractivity: 205.697 cm³
Molar Volume: 575.317 cm³
Polarizability: 81.545×10^-24cm³
Surface Tension: 48.156 dyne/cm
Density: 1.366 g/cm³
Melting Point: 200-205°C(dec)
Physical Appearance: Red-Orange Crystalline Powder
Product Categories: Active Pharmaceutical Ingredients;Antibacterial;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Rifaximin (CAS NO.80621-81-4): (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26S,27S,28E)-5,6,21,23,25 Pentahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca(1,11,13)trienimino)benzofuro(4,5-e)pyrido(1,2-a)benzimidazole-1,15(2H)-dione, 25-acetate ; 4-Deoxy-4'-methylpyrido(1',2'-1,2)imidazo(5,4-c)rifamycin SV ; Fatroximin ; Normix ; Rifacol .

Uses

Rifaximin (CAS NO.80621-81-4) is highly effective at preventing and treating traveler's diarrhea among travelers to Mexico, with few side effects and low risk of developing antibiotic resistance. In the United States, Rifaximin has orphan drug status for the treatment of hepatic encephalopathy.

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	oral	> 2gm/kg (2000mg/kg)		Drugs of the Future. Vol. 7, Pg. 260, 1982.
rat	LD50	oral	> 2gm/kg (2000mg/kg)		Chemioterapia. Vol. 5, Pg. 263, 1986.

Safety Profile

RTECS: KD1576000