Basic information
- Name:
1H-Indole-3-ethanamine,N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
- Superlist Name:
- Rizatriptan
- CAS No.:
144034-80-0
- Molecular Structure:
- Formula:
- C15H19N5
- Molecular Weight:
- 269.34
- Synonyms:
- 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)indole;MK 462 free base;N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine;Risatriptan;Rizatriptan;
- Density:
- 1.21 g/cm3
- Melting Point:
- 178-180 °C
- Boiling Point:
- 504.8 °C at 760 mmHg
- Flash Point:
- 259.1 °C
- Solubility:
- water: 42 mg/mL
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Chemistry
Rizatriptan (144034-80-0) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).
Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.
Rizatriptan(144034-80-0) is available only by prescription in the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv) and Israel (as Rizalt).
The density of Rizatriptan(144034-80-0) is 1.21 g/cm3 and it has a melting point of 178-180°C. The boiling point is 504.8 °C at 760 mmHg. The refractive index is about 1.645. Its flash point is 259.1 °C.
The chemical synonyms of Rizatriptan(144034-80-0) are n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethanamine;RIZATRIPTAN
The molecular structure of Rizatriptan(144034-80-0):