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Cas Database |
| Name |
SELOKEN |
EINECS | N/A |
| CAS No. | 74220-04-5 | Density | N/A |
| PSA | N/A | LogP | N/A |
| Solubility | N/A | Melting Point |
N/A |
| Formula | N/A | Boiling Point | N/A |
| Molecular Weight | 417.456 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
N/A |
Article Data | 3 |
SELOKEN Chemical Properties
IUPAC Name: (2R,3R)-2,3-Dihydroxybutanedioic acid;1-[4-(2-methoxyethyl)phenoxy]-3-(propan-2-ylamino)propan-2-ol
The MF of Seloken (CAS NO.74220-04-5) is C34H56N2O12.
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The MW of Seloken (CAS NO.74220-04-5) is 684.81464.
Synonyms of Seloken (CAS NO.74220-04-5): 1-Isopropylamino-3-(p-(2-methoxyethyl)phenoxy)-2-propanol (2:1) dextro-tartrate salt ; 2-Propanol, 1-(isopropylamino)-3-(p-(2-methoxyethyl)phenoxy)-, (+-)-, tartrate (2:1)
Enthalpy of Vaporization: 68.47 kJ/mol
Flash Point: 194.9 °C
Boiling Point: 398.6 °C
SELOKEN Uses
Seloken (CAS NO.74220-04-5) is a selective adrenergic beta-1-blocking agent with no stimulatory action. It's binding to plasma albumin is weaker than alprenolol and it may be useful in angina pectoris, hypertension, or cardiac arrhythmias.
SELOKEN Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | oral | 1090mg/kg (1090mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983. | |
| human | TDLo | oral | 160mg/kg (160mg/kg) | CARDIAC: PULSE RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: CYANOSIS | British Medical Journal. Vol. 1, Pg. 222, 1976. |
| mouse | LD50 | intraperitoneal | 202mg/kg (202mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982. | |
| mouse | LD50 | intravenous | 84mg/kg (84mg/kg) | Drugs in Japan Vol. -, Pg. 614, 1995. | |
| mouse | LD50 | oral | 1500mg/kg (1500mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979. |
| mouse | LD50 | subcutaneous | 510mg/kg (510mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979. |
| rabbit | LD50 | intravenous | 28700ug/kg (28.7mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983. | |
| rabbit | LD50 | oral | 604mg/kg (604mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 14, Pg. 297, 1983. | |
| rat | LD50 | intraperitoneal | 219mg/kg (219mg/kg) | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 24, Pg. 2439, 1982. | |
| rat | LD50 | intravenous | 90mg/kg (90mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979. |
| rat | LD50 | oral | 5500mg/kg (5500mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979. |
| rat | LD50 | subcutaneous | 1150mg/kg (1150mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 13, Pg. 2839, 1979. |
SELOKEN Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: decreased blood pressure along with possible decrease in pulse rate, and cyanosis. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
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