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Basic information

  • Name:

  • Sodium cyclamate

  • CAS No.:

  • 139-05-9

  • Formula:
  • C6H12NNaO3S
  • Synonyms:
  • Cyclohexanesulfamicacid, monosodium salt (8CI);Sulfamic acid, cyclohexyl-, monosodium salt (9CI);Acofarinas;Assugrin;Asugryn;Azucrona;Cyclamate sodium;Cyclohexylsulfamatesodium;Cyclohexylsulfamic acid sodium salt;N-Cyclohexylsulfamic acid sodium salt;

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Chemistry

IUPAC Name: Sodium N-cyclohexylsulfamate
Synonyms of Sodium cyclamate (CAS NO.139-05-9): Assugrin ; Assurgrin feinsuss ; Assurgrin vollsuss ; Cyclamate de sodium ; Cyclohexanesulfamic acid, monosodium salt ; Cyclohexanesulphamic acid, monosodium salt ; Monosodium cyclohexylsulfamate ; N-Cyklohexylsulfamat sodny ; Sodium cyclohexylsulphamidate ; Sulfamic acid, cylclohexyl-, monosodium salt
CAS NO: 139-05-9
Molecular Formula: C6H12NNaO3S
Molecular Weight: 201.22 
Molecular Structure:
EINECS: 205-348-9 
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 1
Polar Surface Area: 65.99 Å2 
Melting point:  >300 °C(lit.)
Water Solubility:  >=10 g/100 mL at 20 °C
Appearance: White powder
Product Categories: Food & Feed ADDITIVES 
SMILES: [Na+].O=S([O-])(=O)NC1CCCCC1
InChI: InChI=1/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1
InChIKey: UDIPTWFVPPPURJ-REWHXWOFAV
Std. InChI: InChI=1S/C6H13NO3S.Na/c8-11(9,10)7-6-4-2-1-3-5-6;/h6-7H,1-5H2,(H,8,9,10);/q;+1/p-1
Std. InChIKey: UDIPTWFVPPPURJ-UHFFFAOYSA-M

Uses

 Sodium cyclamate (CAS NO.139-05-9) is often used synergistically with other artificial sweeteners, especially saccharin.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1154mg/kg (1154mg/kg)   Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973,
mouse LD50 intravenous 4800mg/kg (4800mg/kg)   Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
mouse LD50 oral 17gm/kg (17000mg/kg)   Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
rat LD50 intraperitoneal 1350mg/kg (1350mg/kg)   Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institut by Bio-Research Consultants, Inc. Vol. NCI-E-68-1311, Pg. 1973,
rat LD50 intravenous 3500mg/kg (3500mg/kg)   Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968.
rat LD50 oral 1280mg/kg (1280mg/kg)   Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.

Consensus Reports

IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 178.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Limited Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 22 ,1980,p. 55.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Safety Profile

Safety Information about Sodium cyclamate (CAS NO.139-05-9):
Hazard Codes: HarmfulXn
Risk Statements: 22 
R22:Harmful if swallowed.
Safety Statements: 36/37
S36/37: Wear suitable protective clothing and gloves.
WGK Germany: 3
RTECS: GV7350000
HS Code: 29299000
Sodium cyclamate has moderately toxic by intravenous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental neoplastigenic, tumorigenic, and teratogenic data. Human mutation data reported. When heated to decomposition it emits very toxic fumes of Na2O, SOx, and NOx.

Specification

 Sodium cyclamate is incompatible with strong oxidizing agents, strong acids and strong bases. It is also incompatible with nitrites in acid solution. And it has only limited compatibility with potassium salts .

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