Basic information
- Name:
Salicylamide
- CAS No.:
65-45-2
- Molecular Structure:
- Formula:
- C7H7NO2
- Molecular Weight:
- 137.14 .
- Synonyms:
- Salamide;Saliamid;Saliamin;Salicim;Salicylic acid amide;Salipur;Salizell;Salrin;Salymid;Samid;Serramida;Urtosal;o-Hydroxybenzamide;Benzamide,2-hydroxy-;Salicylamide(8CI);2-Carbamoylphenol;2-Carboxamidophenol;2-Hydroxybenzamide;Afko-Sal;Algamon;Algiamida;Allevin;Amid-Sal;Amidosal;Anamid;Benesal;Cetamide;Cidal;Dropsprin;Liquiprin;Morsarinas;Novecyl;Oramid;Panithal;Raspberin;Salamid;
- EINECS:
- 200-609-3
- Density:
- 1.286 g/cm3
- Melting Point:
- 140-144 °C(lit.)
- Boiling Point:
- 318.3 °C at 760 mmHg
- Flash Point:
- 146.3 °C
- Solubility:
- <0.1 g/100 mL at 20 °C in water
- Appearance:
- white or light pink crystals or powder
- Hazard Symbols:
Xn- Risk Codes:
- 22-36/37/38-20/21/22
- Safety Description:
- 26-36 Details
- Transport Information:
- UN 3249
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Chemistry
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IUPAC Name: 2-Hydroxybenzamide
Molecular Formula: C7H7NO2
Molecular Weight: 137.14 g/mol
SMILES: O=C(c1ccccc1O)N Copy
InChI: InChI=1/C7H7NO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H,(H2,8,10)
EINECS: 200-609-3
Classification Code: Analgesic; Analgesics; Analgesics, Non-Narcotic; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Drug / Therapeutic Agent; Peripheral Nervous System Agents; Reproductive Effect; Sensory System Agents; Skin / Eye Irritant
Index of Refraction: 1.612
Molar Refractivity: 37.06 cm3
Molar Volume: 106.5 cm3
Surface Tension: 60.1 dyne/cm
Density: 1.286 g/cm3
Flash Point: 146.3 °C
Enthalpy of Vaporization: 58.21 kJ/mol
Boiling Point: 318.3 °C at 760 mmHg
Melting Point: 140-144 °C(lit.)
solubility: methanol: 0.1 g/mL, clear
Water Solubility: <0.1 g/100 mL at 20 °C
Stability: Stable. Light sensitive. Incompatible with strong bases, strong oxidizing agents.
Vapour Pressure of Salicylamide (CAS NO.65-45-2): 0.000195 mmHg at 25 °C
Uses
Salicylamide (CAS NO.65-45-2) is used in combination with both aspirin and caffeine in the over-the-counter pain remedy known as BC Powder.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| cat | LDLo | oral | 150mg/kg (150mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| dog | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| guinea pig | LD50 | oral | 1730mg/kg (1730mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
| guinea pig | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| mouse | LD50 | intraperitoneal | 180mg/kg (180mg/kg) | Bollettino Chimico Farmaceutico. Vol. 111, Pg. 293, 1972. | |
| mouse | LD50 | intravenous | 313mg/kg (313mg/kg) | BEHAVIORAL: GENERAL ANESTHETIC | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| mouse | LD50 | oral | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| mouse | LD50 | subcutaneous | 300mg/kg (300mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 25, 1958. | |
| rabbit | LD50 | oral | 3200mg/kg (3200mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 5, Pg. 572, 1955. | |
| rabbit | LDLo | intraperitoneal | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Journal of Pharmacology and Experimental Therapeutics. Vol. 101, Pg. 119, 1951. |
| rat | LD50 | intraperitoneal | 600mg/kg (600mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 108, Pg. 450, 1953. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 47, Pg. 479, 1958. |
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 22-36/37/38-20/21/22
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR: 3249
WGK Germany: 3
RTECS: VN6475000
HazardClass: 6.1(b)
PackingGroup of Salicylamide (CAS NO.65-45-2): III
Specification
Salicylamide (CAS NO.65-45-2), its Synonyms are 2-Hydroxybenzamide ; Benzamide, 2-hydroxy- ; 2-Carbamoylphenol ; 2-Carboxamidophenol ; Acket ; Afko-Sal ; Algamon ; Algiamida ; Allevin ; Amid kyseliny salicylove ; o-Hydroxybenzamide . It is odorless white or slightly pink crystals and bitter taste, leaves a sensation of warmth on the tongue.