IARC Cancer Review: Group 3 IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 56.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 12 ,1976,p. 209.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . Reported in EPA TSCA Inventory. EPA Extremely Hazardous Substances List.

The IUPAC name of Semicarbazide hydrochloride is aminourea hydrochloride. With the CAS registry number 563-41-7, it is also named as Carbamylhydrazine hydrochloride. The product's categories are bases & related reagents; inhibitors; nucleotides. It is white solid which is soluble in water, soluble in ethanol and ether. In addition, this chemical should be sealed in the container and placed in the cool and dry aera.

The other characteristics of this product can be summarized as: (1)ACD/LogP: -2.75; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): -2.75; (4)ACD/LogD (pH 7.4): -2.75; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 5; (11)#Freely Rotating Bonds: 1; (12)Flash Point: 96.1 °C; (13)Enthalpy of Vaporization: 48.17 kJ/mol; (14)Boiling Point: 235.3 °C at 760 mmHg; (15)Vapour Pressure: 0.0407 mmHg at 25°C; (16)Tautomer Count: 3; (17)Exact Mass: 111.01994; (18)Topological Polar Surface Area: 81.1; (19)Heavy Atom Count: 6; (20)Complexity: 42.2.

Preparation of Semicarbazide hydrochloride: The condensation of hydrazine hydrate and urea to get semicarbazide solution which is acidified by hydrochloric acid. Then we can get the product after cold crystallization by water.

Uses of Semicarbazide hydrochloride: It is used as intermediate of medicine and pesticide, such as used in the production of nitrofurazone, nitrofurantoin drugs. And it is also used as analytical reagent and chromatography reagent. Additionlly, it can react with 3-methyl-butan-2-one to obtain 3-methyl-butan-2-one semicarbazone. This reaction needs reagent potassium acetate and water.

When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed, so people should not breathe dust. And it is also irritating to eyes and skin, so people must avoid contact with skin and eyes. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Avoid exposure - obtain special instructions before use.

People can use the following data to convert to the molecule structure.
1. SMILES:Cl.O=C(N)NN
2. InChI:InChI=1/CH5N3O.ClH/c2-1(5)4-3;/h3H2,(H3,2,4,5);1H 

The following are the toxicity data which has been tested.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	145mg/kg (145mg/kg)		Farmakologiya i Toksikologiya Vol. 24, Pg. 623, 1961.
mouse	LD50	oral	225mg/kg (225mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 686, 1960.
mouse	LD50	subcutaneous	167mg/kg (167mg/kg)		Acta Biologica et Medica Germanica. Vol. 21, Pg. 635, 1968.
rabbit	LDLo	oral	400mg/kg (400mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA BEHAVIORAL: EXCITEMENT	Farmakologiya i Toksikologiya Vol. 24, Pg. 623, 1961.
rat	LD	intraperitoneal	> 98mg/kg (98mg/kg)	VASCULAR: STRICTIRA; CJAMGES OM VESSE;S	Toxicology and Applied Pharmacology. Vol. 155, Pg. 237, 1999.
rat	LDLo	oral	10mg/kg (10mg/kg)		National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. Vol. 5, Pg. 44, 1953.