Serotonin as originally discovered by Italian Vittorio Erspamer in Rome in 1935 and American scientists in the late 1940s. In 1948, it was isolated and named by Maurice M. Rapport, Arda Green, and Irvine Page of the Cleveland Clinic. It was initially identified as a vasoconstrictor substance in blood serum – hence serotonin, a serum agent affecting vascular tone. Serotonin was later chemically identified as 5-hydroxytryptamine (5-HT) by Rapport, and, as the broad range of physiological roles were elucidated, 5-HT became the preferred name in the pharmacological field.

The Serotonin, with the CAS registry number 50-67-9, is also known as 5-Hydroxytryptamine. It belongs to the product categories of Tryptamines; Standards - 13C & 2H for GC-Mass Spectrometry. Its EINECS number is 200-058-9. This chemical's molecular formula is C₁₀H₁₂N₂O and molecular weight is 176.21. What's more, its systematic name is 3-(2-Aminoethyl)-1H-indol-5-ol. Its classification codes are: (1)Drug / Therapeutic Agent; (2)Neurotransmitter Agents; (3)Reproductive Effect; (4)Serotonin Agents; (5)Serotonin Receptor Agonists. This chemical is a monoamine neurotransmitter. It is used as a boiler water softener, degreasing detergent, metal corrosion inhibitor or anti-rust agent.

Physical properties of Serotonin are: (1)ACD/LogP: 0.545; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2.53; (4)ACD/LogD (pH 7.4): -1.74; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.00; (9)#H bond acceptors: 3; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 62.04 Å²; (13)Index of Refraction: 1.711; (14)Molar Refractivity: 53.495 cm³; (15)Molar Volume: 136.796 cm³; (16)Polarizability: 21.207×10^-24cm³; (17)Surface Tension: 67.0 dyne/cm; (18)Density: 1.288 g/cm³; (19)Flash Point: 205.443 °C; (20)Enthalpy of Vaporization: 69.524 kJ/mol; (21)Boiling Point: 416.089 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.

Preparation: this chemical can be prepared by 2-(5-methoxy-indol-3-yl)-ethylamine at the temperature of 20 °C. This reaction will need reagent BBr₃ and solvent CH₂Cl₂. The yield is about 65%.

Uses of Serotonin: it can be used to produce N-Benzyloxycarbonyl-5-hydroxytryptamin at the ambient temperature. It will need reagent Na₂CO₃ and solvent H₂O with the reaction time of 6 hours. The yield is about 84%.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc2c(cc1O)c(c[nH]2)CCN
(2)Std. InChI: InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
(3)Std. InChIKey: QZAYGJVTTNCVMB-UHFFFAOYSA-N

The toxicity data is as follows: