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Sibutramine

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Name Sibutramine EINECS
CAS No. 106650-56-0 Density 1.031 g/cm3
Solubility Water solubility: 2.9 mg/mL Melting Point 191-192 °C
Formula C17H26ClN Boiling Point 342.6 °C at 760 mmHg
Molecular Weight 334.33 Flash Point 161 °C
Transport Information 25kgs Appearance Yellowish solid
Safety Risk Codes
Molecular Structure Molecular Structure of 106650-56-0 (Cyclobutanemethanamine,1-(4-chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)-) Hazard Symbols
Synonyms

UNII-WV5EC51866;Didemethylsibutramine hydrochloride;Medaria;Racemic sibutramine;

 

Chemistry

Molecular Structure:

Molecular Formula: C17H26ClN
Molecular Weight: 279.848
IUPAC Name: 1-[1-(4-Chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine
Synonyms of Sibutramine (CAS NO.106650-56-0): Sibutramine [INN:BAN] ; Medaria ; Reductil ; Sibutramina ; Sibutramina [Spanish] ; Sibutraminum ; Sibutraminum [Latin] ; UNII-WV5EC51866 ; Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)- ; DEA No. 1675
CAS NO: 106650-56-0
Classification Code: Anti-Obesity Agents ; Antidepressive agents ; Appetite depressants ; Central Nervous System Agents ; Psychotropic Drugs
Melting point: 191-192°C 
Index of Refraction: 1.529
Molar Refractivity: 83.76 cm3
Molar Volume: 271.3 cm3
Surface Tension: 37.3 dyne/cm
Density: 1.031 g/cm3
Flash Point: 161 °C
Enthalpy of Vaporization: 58.64 kJ/mol
Boiling Point: 342.6 °C at 760 mmHg
Vapour Pressure: 7.45E-05 mmHg at 25°C

Uses

 Sibutramine (CAS NO.106650-56-0) has been used as an appetite suppressant administered orally for the treatment of obesity.

Specification

  Sibutramine (CAS NO.106650-56-0) is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines, and is also under review by the FDA and the European Medicines Agency. It is classified as a Schedule IV controlled substance in the United States, despite having virtually no potential for misuse due to its lack of appreciable dopaminergic effects. As a neurotransmitter reuptake inhibitor, it reduces the reuptake of serotonin (by 53%), norepinephrine (by 54%), and dopamine (by 16%), thereby increasing the levels of these substances in synaptic clefts and helping enhance satiety. It has a number of clinically significant interactions, and a higher number of cardiovascular events has been observed in people taking it verses control (11.4% vs. 10.0%).

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