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Sodium Citrate (68-04-2)

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Chemistry

Molecular Structure:

Molecular Formula: C6H5Na3O7
Molecular Weight: 258.069
IUPAC Name: Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Synonyms of Sodium Citrate (CAS NO.68-04-2): 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt ; CCRIS 3293 ; Citnatin ; Citreme ; Citric acid, trisodium salt ; Citrosodina ; Citrosodine ; Citrosodna ; EINECS 200-675-3 ; FEMA No. 3026 ; HSDB 5201 ; Natrocitral ; Sodium citrate (Na3C6H5O7) ; Sodium citrate anhydrous ; Trisodium 2-hydroxy-1,2,3-propanetricarboxylate ; Trisodium citrate ; Trisodium citrate, anhydrous ; UNII-RS7A450LGA
CAS NO: 68-04-2
Classification Code: FOOD ADDITIVES ; Chemistry ; Cytochemistry Products ; Hematology and Histology ; ReagentsMore...Close... ; AlphabeticalMolecular Biology ; Biological Buffers ; BioUltra Buffers ; BioUltraBiological Buffers ; Buffer SolutionsBiochemicals and Reagents ; ChelatorsProtein Structural Analysis ; DNA&RNA Purification ; Molecular Biology Reagents ; Optimization ReagentsMolecular Biology ; X-Ray Crystallography ; Buffers A to Z ; AnticoagulantsBiological Buffers ; Buffers A to ZProteins and Derivatives ; Blood ; Buffer Convenience Packaging ; Buffer SolutionsBiological Buffers ; Coagulation Proteins and Reagents ; Immune Cell Signaling and Blood ; Plasma&Blood Proteins
Melting point: 300°C 
H bond acceptors: 7
H bond donors: 4
Freely Rotating Bonds: 6
Polar Surface Area: 121.13 Å2
Flash Point: 155.2 °C
Enthalpy of Vaporization: 63.82 kJ/mol
Boiling Point: 309.6 °C at 760 mmHg
Vapour Pressure: 5.73E-05 mmHg at 25°C

Uses

  Sodium Citrate (CAS NO.68-04-2) is used as a flavoring agent in certain varieties of club soda.
It is an ingredient in Benedict's reagent and is used by Canadian Blood Services as an anticoagulant during apheresis. When it comes in contact with water, it is a product of the chemical reaction Alka Seltzer produces.Sodium citrate is used in the relief of cystitis in women, its effect is to make the urine less acidic and therefore provide pain relief. Its is not recommended for children or men to use it.
 

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1364mg/kg (1364mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
mouse LD50 intravenous 170mg/kg (170mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
rabbit LD50 intravenous 449mg/kg (449mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
rat LD50 intraperitoneal 1548mg/kg (1548mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.

Safety Profile

Risk Statements of Sodium Citrate (CAS NO.68-04-2): 20-40-48/22 
R20: Harmful by inhalation.
R40: Limited evidence of a carcinogenic effect. 
R48/22: Harmful: danger of serious damage to health by prolonged exposure if swallowed.
Safety Statements: 36-24/25 
S36: Wear suitable protective clothing. 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
F: 34