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Sodium Cyanide

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Name

Sodium Cyanide

EINECS 205-599-4
CAS No. 143-33-9 Density 1.6 g/cm3
PSA 23.79000 LogP 0.01678
Solubility 37 g/100mL (20 °C) in water Melting Point 563.7 °C
Formula NaCN Boiling Point 1497 °C
Molecular Weight 49.0075 Flash Point 1500°C
Transport Information UN 1689 6.1/PG 1 Appearance white crystals
Safety 7-28-29-45-60-61-28A Risk Codes 26/27/28-32-50/53
Molecular Structure Molecular Structure of 143-33-9 (Sodium cyanide) Hazard Symbols VeryT+,DangerousN
Synonyms

Sodiumcyanide (8CI);Cyanasalt H;Cyanasalt S;Cymag;NSC 77379;Natrium cyanide;Sodium cyanide (Na(CN));sodium cyanide 98%;

Article Data 128

Sodium Cyanide Synthetic route

107126-37-4

α-benzyloxy-α-phenyl-as-triazine-5-acetonitrile

A

143-33-9

sodium cyanide

B

107126-34-1

5-benzoyl-6-methyl-3-phenyl-as-triazine

C

65-85-0

benzoic acid

Conditions
ConditionsYield
With sodium hydroxide In water; dimethyl sulfoxideA n/a
B 54%
C n/a
67-56-1

methanol

6011-99-0

benzo[d]thiazol-2-yl thiocyanate

143-33-9

sodium cyanide

Conditions
ConditionsYield
at 22 - 27℃;
at 22 - 27℃;
60-29-7

diethyl ether

506-68-3

bromocyane

996-82-7

sodium diethylmalonate

A

4513-67-1

diethyl 2-cyanomalonate

B

6174-95-4

1,1,2,2-tetracarboethoxy-ethylene

C

632-56-4

tetraethyl ethane-1,1,2,2-tetracarboxylate

D

143-33-9

sodium cyanide

506-68-3

bromocyane

64-17-5

ethanol

996-82-7

sodium diethylmalonate

A

4513-67-1

diethyl 2-cyanomalonate

B

6174-95-4

1,1,2,2-tetracarboethoxy-ethylene

C

632-56-4

tetraethyl ethane-1,1,2,2-tetracarboxylate

D

143-33-9

sodium cyanide

506-68-3

bromocyane

64-17-5

ethanol

996-82-7

sodium diethylmalonate

A

6174-95-4

1,1,2,2-tetracarboethoxy-ethylene

B

143-33-9

sodium cyanide

74-90-8

hydrogen cyanide

141-52-6

sodium ethanolate

143-33-9

sodium cyanide

74-90-8

hydrogen cyanide

141-53-7

sodium formate

143-33-9

sodium cyanide

74-90-8

hydrogen cyanide

143-33-9

sodium cyanide

Conditions
ConditionsYield
With sodium hydroxide
With sodium hydroxide; ethanol
With sodium hydroxide at 200 - 300℃;
13534-15-1, 88770-07-4

diethyl oximidate

141-52-6

sodium ethanolate

A

2812-77-3

diethyl imidocarbonate

B

143-33-9

sodium cyanide

816-27-3

ethyl 2-ethoxy-2-iminoacetate

141-52-6

sodium ethanolate

A

143-33-9

sodium cyanide

B

105-58-8

Diethyl carbonate

Sodium Cyanide Consensus Reports

EPA Extremely Hazardous Substances List. Cyanide and its compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

Sodium Cyanide Standards and Recommendations

OSHA PEL: TWA 5 mg(CN)/m3 (skin)
ACGIH TLV: CL 5 mg(CN)/m3 (skin)
DFG MAK: 5 mg(CN)/m3
NIOSH REL: CL 5 mg(CN)/m3/10M
DOT Classification:  6.1; Label: Poison

Sodium Cyanide Analytical Methods

For occupational chemical analysis use NIOSH: Cyanides, 7904.

Sodium Cyanide Specification

The sodium cyanide. With the CAS registry number 143-33-9, it is also named as Hydrocyanic acid, sodium salt. The product's categories are Sodium Cyanide; Inorganics; Peroxidase Inhibitors; Essential Chemicals; Reagent Grade; Routine Reagents; Molecular Biology; Molecular Biology Reagents; Superoxide Dismutase. The structure of solid NaCN is related to that of sodium chloride. It is white crystals with faint odor of bitter almond, which is soluble in water, ammonia, ethanol and methanol. When contact with acid and water, it liberates very toxic gas. Additionally, this chemical should be sealed in the container and stored in the cool, ventilate and dry place. Keep Sodium Cyanide separate from alkali, acids and food additives.

Physical properties about sodium cyanide are: 
 (1)H-Bond Donor: 0; (2)H-Bond Acceptor: 2; (3)Rotatable Bond Count: 0; (4)Exact Mass: 48.992844; (5)MonoIsotopic Mass: 48.992844; (6)Topological Polar Surface Area: 23.8; (7)Heavy Atom Count: 3; (8)Formal Charge: 0; (9)Complexity: 12.8; (10)Covalently-Bonded Unit Count: 2.

Preparation of Sodium Cyanide:
 It can be obtained by treating hydrogen cyanide with sodium hydroxide: 
                      HCN + NaOH → NaCN + H2O

Uses of Sodium Cyanide:
 It is mainly used to extract gold and other precious metals in mining. 
                      4 Au + 8 NaCN + O2 + 2 H2O → 4 Na[Au(CN)2] + 4 NaOH 
It is also used to kill or stun rapidly such as in illegal cyanide fishing and in collecting jars used by entomologists. What's more, this chemica is used in plastics, pharmaceuticals, pesticides, dyes, metallurgy, electroplating, mineral processing and other industries. In addition, it can react with cycloheptanone to get 4-cyanocycloheptanone. This reaction needs reagents Na2S2O8, Na2SO4 and solvent water at temperature of 80 °C. The reaction time is 5 hours. The yield is 35%.
Uses of Sodium Cyanide

Safety Information of Sodium Cyanide:
It is not only very toxic by inhalation, in contact with skin and if swallowed, but also very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. After contact with skin, wash immediately with plenty of soap-suds. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) This material and its container must be disposed of as hazardous waste. And people should avoid release it to the environment. Refer to special instructions / safety data sheets.

You can still convert the following datas into molecular structure:
1. SMILES:[C-]#N.[Na+]
2. InChI:InChI=1/CN.Na/c1-2;/q-1;+1
3. InChIKey:MNWBNISUBARLIT-UHFFFAOYAG

The toxicity data of Sodium Cyanide is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 4mg/kg (4mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986.
chicken LD50 oral 21mg/kg (21mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986.
child LDLo oral 100mg/kg (100mg/kg) GASTROINTESTINAL: OTHER CHANGES Forensic Science International. Vol. 38, Pg. 173, 1988.
dog LD50 subcutaneous 5360ug/kg (5.36mg/kg)   JAMA, Journal of the American Medical Association. Vol. 149, Pg. 113, 1952.
dog LDLo intravenous 1300ug/kg (1.3mg/kg)   Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 6, Pg. 349, 1947.
domestic animals - goat/sheep LD50 oral 4mg/kg (4mg/kg)   Toxicology and Applied Pharmacology. Vol. 45, Pg. 359, 1978.
duck LD50 oral 2500ug/kg (2.5mg/kg)   National Technical Information Service. Vol. OTS0530251,
frog LDLo parenteral 60mg/kg (60mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
guinea pig LD50 subcutaneous 5800ug/kg (5.8mg/kg)   Medicina del Lavoro. Industrial Medicine. Vol. 46, Pg. 221, 1955.
human LDLo oral 2800ug/kg (2.8mg/kg)   National Technical Information Service. Vol. OTS0528336,
human LDLo oral 2857ug/kg (2.857mg/kg)   "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 191, 1969.
mammal (species unspecified) LD50 oral 8mg/kg (8mg/kg)   Bulletin of Environmental Contamination and Toxicology. Vol. 23, Pg. 211, 1979.
man LDLo oral 6557ug/kg (6.557mg/kg) BEHAVIORAL: FLUID INTAKE

GASTROINTESTINAL: GASTRITIS
Acta Pharmacologica et Toxicologica. Vol. 1, Pg. 18, 1945.
man LDLo unreported 2206ug/kg (2.206mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo oral 714ug/kg (0.714mg/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

BEHAVIORAL: MUSCLE WEAKNESS
Acta Pharmacologica et Toxicologica. Vol. 20, Pg. 291, 1963.
 
mouse LD50 intraperitoneal 4900ug/kg (4.9mg/kg)   National Technical Information Service. Vol. OTS0528336,
mouse LD50 subcutaneous 3600ug/kg (3.6mg/kg)   American Journal of Physiology. Vol. 179, Pg. 60, 1954.
 
mouse LD50 unreported 10mg/kg (10mg/kg)   Igaku No Ayumi. Progress in Medicine. Vol. 112, Pg. 861, 1980.
quail LD50 oral 8500ug/kg (8.5mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of Wildlife Diseases. Vol. 22, Pg. 538, 1986.
 
rabbit LD50 intramuscular 1666ug/kg (1.666mg/kg)   Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982.
rabbit LD50 ocular 5048ug/kg (5.048mg/kg)   Journal of the American College of Toxicology. Vol. 1(3), Pg. 120, 1982.
rabbit LD50 skin 10400ug/kg (10.4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: TREMOR
National Technical Information Service. Vol. OTS0536153,
rabbit LDLo subcutaneous 2200ug/kg (2.2mg/kg)   JAMA, Journal of the American Medical Association. Vol. 100, Pg. 1920, 1933.
rat LD50 intraperitoneal 4300ug/kg (4.3mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(12), Pg. 90, 1978.
rat LD50 oral 6440ug/kg (6.44mg/kg)   "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 13, 1972.
women LDLo oral 40mg/kg (40mg/kg) GASTROINTESTINAL: OTHER CHANGES Forensic Science International. Vol. 38, Pg. 173, 1988.

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