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Sodium propylparaben
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Name

Sodium propylparaben

 EINECS 252-488-1
CAS No. 35285-69-9 Density 1.24 g/cm3 (25 °C)
PSA 49.36000 LogP 2.39720
Solubility 1000g/L at 23℃ Melting Point 96-97oC
Formula C10H11NaO3 Boiling Point 294.3 °C at 760 mmHg
Molecular Weight 202.185 Flash Point 124.6 °C
Transport Information N/A Appearance White hygroscopic powder
Safety 22-24/25 Risk Codes N/A
Molecular Structure Molecular Structure of 35285-69-9 (4-Hydroxybenzoic acid propyl ester sodium salt) Hazard Symbols N/A
Synonyms

Benzoicacid, 4-hydroxy-, propyl ester, sodium salt (9CI);Nipasol M Sodium;Propyl 4-hydroxybenzoate sodium salt;Propyl p-hydroxybenzoate sodium salt;Propylparaben sodium;Sodium propyl 4-hydroxybenzoate;Sodium propylp-hydroxybenzoate;

Article Data 1

Sodium propylparaben Synthetic route

94-13-3

nipasol

35285-69-9

sodium propyl paraben

Conditions
ConditionsYield
With sodium hydride In diethylene glycol dimethyl ether Product distribution / selectivity;
35285-69-9

sodium propyl paraben

2614-88-2

sorbinyl chloride

88973-91-5

4-((2E,4E)-Hexa-2,4-dienoyloxy)-benzoic acid propyl ester

Conditions
ConditionsYield
85%
3445-11-2

1-(2-hydroxyethyl)-2-pyrrolidinone

polydichlorophosphazene

polydichlorophosphazene

35285-69-9

sodium propyl paraben

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

Conditions
ConditionsYield
Stage #1: 1-(2-hydroxyethyl)-2-pyrrolidinone With sodium hydride In 1,4-dioxane
Stage #2: sodium propyl paraben In 1,4-dioxane; diethylene glycol dimethyl ether at 20℃;
Stage #3: polydichlorophosphazene With potassium hydroxide; water more than 3 stages;		75%
polydichlorophosphazene

polydichlorophosphazene

866641-89-6

sodium 1-(2-hydroxyethyl)-2-pyrrolidone

35285-69-9

sodium propyl paraben

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

poly{[2-(2-oxo-1-pyrrolidinyl)ethoxy](4-carboxylatophenoxy)phosphazene}

Conditions
ConditionsYield
Stage #1: polydichlorophosphazene; sodium propyl paraben In diethylene glycol dimethyl ether at 50 - 100℃; for 3h;
Stage #2: sodium 1-(2-hydroxyethyl)-2-pyrrolidone In 1,4-dioxane; diethylene glycol dimethyl ether at 50℃; for 20h;
Stage #3: With hydrogenchloride; potassium hydroxide; water; ammonium bicarbonate more than 3 stages;		38.6%
94-13-3

nipasol

35285-69-9

sodium propyl paraben

poly[di(4-propoxycarbonylphenoxy)phosphazene]; monomer(s): sodium propyl paraben; propyl 4-hydroxybenzoate

poly[di(4-propoxycarbonylphenoxy)phosphazene]; monomer(s): sodium propyl paraben; propyl 4-hydroxybenzoate

Conditions
ConditionsYield
With poly(dichlorophosphazene) In diethylene glycol dimethyl ether for 8h; Heating;

Sodium propylparaben Chemical Properties

Structure of Sodium propylparaben (CAS NO.35285-69-9):

Molecular Formula: C10H11NaO3
Formula Weight: 202.18 g/mol
EINECS: 252-488-1 
Flash Point: 124.6 °C 
Enthalpy of Vaporization: 55.53 kJ/mol 
Boiling Point: 294.3 °C at 760 mmHg
Vapour Pressure: 0.00093 mmHg at 25°C 
Solubility: Soluble in water
Appearance: White hygroscopic powder
Product Category of Sodium propylparaben (CAS NO.35285-69-9): Aromatic Esters

Sodium propylparaben Uses

 Sodium propylparaben (CAS NO.35285-69-9) is widely for corrosion in pharmaceutical, food, textile industries, and other areas such as cosmetics, feed, daily industrial anti-corrosion.

Sodium propylparaben Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 85mg/kg (85mg/kg)   Drug Standards. Vol. 20, Pg. 89, 1952.
mouse LD50 intraperitoneal 490mg/kg (490mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.
mouse LD50 intravenous 180mg/kg (180mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.
mouse LD50 oral 3700mg/kg (3700mg/kg)   Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 45, Pg. 260, 1956.

Sodium propylparaben Safety Profile

Safety Statements: 22-24/25
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes.
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Na2O.

Sodium propylparaben Standards and Recommendations

ASSAY: 99.0% min
CHLORIDE: 350ppm max
SULFATE: 300ppm max
HEAVY METALS: 10ppm max
MOISTURE: 5.0% max

Sodium propylparaben Specification

 Sodium propylparaben , its cas register number is 35285-69-9. It also can be called Propyl p-hydroxybenzoate sodium salt ; Propylparaben sodium ; Sodium propyl p-hydroxybenzoate ; 4-Hydroxybenzoic acid propyl ester sodium salt ; and Sodium Propyl 4-hydroxybenzoate sodium salt . Sodium propylparaben (CAS NO.35285-69-9) should be kept in a cool, well-ventilated place. Combustible materials should be stored away from extreme heat and away from strong oxidizing agents.

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