Basic information
- Name:
Sodium saccharin
- CAS No.:
128-44-9
- Molecular Structure:
- Formula:
- C7H4NNaO3S
- Molecular Weight:
- 205.17
- Deleted CAS:
- 38279-26-4
- Synonyms:
- 1,2-Benzisothiazol-3(2H)-one,1,1-dioxide, sodium salt (1:1);Saccharine Sodium USP;1,2-Benzisothiazol-3(2H)-one,1,1-dioxide, sodium salt (9CI);1,2-Benzisothiazolin-3-one, 1,1-dioxide, sodiumderiv. (7CI);1,2-Benzisothiazolin-3-one, 1,1-dioxide, sodium salt (8CI);Saccharin, sodium deriv. (6CI);1,2-Benzothiazol-3(2H)-one 1,1-dioxide sodiumsalt;Cristallose;Crystallose;Kristallose;Saxin;Sodium o-benzosulfimide;Sodiumo-sulfobenzimide;Sucram C 150;Sweeta;Sykose;Willosetten;o-Benzoylsulfimide sodium salt;
- EINECS:
- 204-886-1
- Melting Point:
- >300 °C
- Boiling Point:
- 438.9 °C at 760 mmHg
- Flash Point:
- 219.3 °C
- Solubility:
- >=10 g/100 mL at 20 °C in water
- Appearance:
- white crystalline powder
- Safety Description:
- 24/25 Details
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Chemistry
Molecular Structure: 
Molecular Formula: C7H4NNaO3S
Molecular Weight: 205.16
CAS NO: 128-44-9
EINECS: 204-886-1
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 0
Polar Surface Area: 75.11 Å2
Flash Point: 219.3 °C
Enthalpy of Vaporization: 73.34 kJ/mol
Boiling Point: 438.9 °C at 760 mmHg
Vapour Pressure: 1.77E-08 mmHg at 25°C
Melting Point: >300°C
Storage temp: 0-6°C
Solubility H2O: 1 M at 20 °C, clear, colorless
Water Solubility: >=10 g/100 mL at 20°C
Stability: Stable. Incompatible with strong oxidizing agents.
Appearance: white powder
IUPAC Name: Sodium 1,1-dioxo-1,2-benzothiazol-2-id-3-one
Sodium saccharin (CAS NO.128-44-9) is also called Sodium 1,2-Benzisothiasolin-3-one-1,1-dioxide and 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide sodium salt .
Product Categories: Food and Feed Additive;Classes of Metal Compounds;Na (Sodium) Compounds (excluding simple sodium salts);Typical Metal Compounds
Uses
Sodium saccharin (CAS NO: 128-44-9) is used as food sweeteners and diagnostic drugs.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 6gm/kg (6000mg/kg) | United States Patent Document. Vol. #4869913, | |
| mouse | LD50 | oral | 17500mg/kg (17500mg/kg) | Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968. | |
| mouse | LDLo | subcutaneous | 7gm/kg (7000mg/kg) | Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981. | |
| rabbit | LDLo | oral | 4gm/kg (4000mg/kg) | Yakkyoku. Pharmacy. Vol. 32, Pg. 1367, 1981. | |
| rat | LD50 | intraperitoneal | 7100mg/kg (7100mg/kg) | Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968. | |
| rat | LD50 | oral | 14200mg/kg (14200mg/kg) | Food and Cosmetics Toxicology. Vol. 6, Pg. 313, 1968. |
Consensus Reports
IARC Cancer Review: Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 ,1987,p. 334.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 22 ,1980,p. 111.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.
Safety Profile
Safety Statements: 24/25
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: DE4550000
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and intraperitoneal routes. A promoter. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, Na2O, and NOx.
Specification
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation. Use only in a chemical fume hood.
Storage: Store in a cool, dry place. Store in a tightly closed container.