Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Sulfadiazine

Related Products

Hot Products

Name

Sulfadiazine

EINECS 200-685-8
CAS No. 68-35-9 Density 1.496 g/cm3
PSA 106.35000 LogP 2.59460
Solubility Very slightly soluble in cold water Melting Point 254 °C
Formula C10H10N4O2S Boiling Point 512.6 °C at 760 mmHg
Molecular Weight 250.281 Flash Point 263.8 °C
Transport Information N/A Appearance White to slightly yellow crystalline powder
Safety 26-36 Risk Codes 22-36/37/38-42/43
Molecular Structure Molecular Structure of 68-35-9 (Sulfadiazine) Hazard Symbols HarmfulXn,IrritantXi
Synonyms

Sulfanilamide,N1-2(1H)-pyrimidinylidene- (6CI);Sulfanilamide, N1-2-pyrimidinyl- (8CI);2-(4-Aminobenzenesulfonylamino)pyrimidine;2-(p-Aminobenzenesulfonamido)pyrimidin;4-Amino-N-(2-pyrimidinyl)benzenesulfonamide;4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline;Adiazine;Cremodiazine;Debenal;Deltazina;Di-Azo-Mul;Diazin;Diazovit;Diazyl;Lipo-Levazine;Liquadiazine;N1-2-Pyrimidylsulfanilamide;Neazine;Pirimal;Pyrimal;RP 2616;Spofadrizine;Sterazine;Sulfadiazine;Sulfapirimidin;Sulfazin (Russian pharmaceutical);Sulfazine;Sulfolex;Sulphadiazine E;Sulfadiazine (SD);

Article Data 29

Sulfadiazine Synthetic route

109-12-6

2-aminopyrimidine

121-60-8

p-acetylaminobenzenesulfonyl chloride

68-35-9

sulfadiazine

Conditions
ConditionsYield
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With calcium carbonate In toluene at 20 - 65℃;
Stage #2: With water; sodium hydroxide In toluene at 100 - 115℃;
Stage #3: With acetic acid pH=5 - 5.5; Reagent/catalyst;
98.5%
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h; Inert atmosphere;
Stage #2: With sodium hydroxide for 2h; Inert atmosphere; Reflux;
65%
Stage #1: 2-aminopyrimidine; p-acetylaminobenzenesulfonyl chloride With pyridine In tetrahydrofuran at 20℃; for 6h;
Stage #2: With sodium hydroxide for 2h; Reflux;
77218-33-8

N-benzylidene-sulfanilic acid pyrimidin-2-ylamide

68-35-9

sulfadiazine

Conditions
ConditionsYield
With water In acetone at 20℃; for 0.666667h; Irradiation;98%
57-67-0

4-amino-N-(diaminomethylene) benzenesulfonamide

19060-08-3

3-ethoxyacrolein

68-35-9

sulfadiazine

Conditions
ConditionsYield
In ethanol at 100℃; for 4h; Green chemistry;91%
4652-39-5

3-butoxyacrolein

57-67-0

4-amino-N-(diaminomethylene) benzenesulfonamide

68-35-9

sulfadiazine

Conditions
ConditionsYield
In butan-1-ol at 100℃; for 4h; Green chemistry;90.8%
542-78-9

Malondialdehyde

57-67-0

1-amino-4-({[amino(imino)methyl]amino}sulfonyl)benzene

68-35-9

sulfadiazine

Conditions
ConditionsYield
With sodium methylate In methanol at 65℃; for 2h; Temperature;89%
4652-35-1

3-methoxyacrolein

57-67-0

4-amino-N-(diaminomethylene) benzenesulfonamide

68-35-9

sulfadiazine

Conditions
ConditionsYield
In methanol at 100℃; for 4h; Temperature; Green chemistry;87%
109-12-6

2-aminopyrimidine

101570-35-8

3-(4-acetylamino-benzenesulfonyl)-2-benzenesulfonylimino-2,3-dihydro-thiazole

68-35-9

sulfadiazine

Conditions
ConditionsYield
und anschliessenden Erhitzen mit wss. NaOH;
109-12-6

2-aminopyrimidine

phenyl-methanesulfonic acid-[3-(N-acetyl-sulfanilyl)-3H-thiazol-2-ylidenamide]

68-35-9

sulfadiazine

Conditions
ConditionsYield
und anschliessenden Erhitzen mit wss. NaOH;
1722-12-9

2-chloropyrimidine

63-74-1

sulfanilamide

68-35-9

sulfadiazine

Conditions
ConditionsYield
With potassium carbonate
18213-90-6

2-phenoxypyrimidine

63-74-1

sulfanilamide

68-35-9

sulfadiazine

Conditions
ConditionsYield
With potassium carbonate

Sulfadiazine Consensus Reports

Reported in EPA TSCA Inventory.

Sulfadiazine Specification

The Sulfadiazine, with the CAS registry number 68-35-9, is also known as Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-. It belongs to the product categories of Antibiotics for Research and Experimental Use; Biochemistry; Sulfonamides (Antibiotics for Research and Experimental Use). Its EINECS registry number is 200-685-8. This chemical's molecular formula is C10H10N4O2S and molecular weight is 250.277. Its IUPAC name is called 4-amino-N-pyrimidin-2-ylbenzenesulfonamide. Side effects reported for sulfadiazine include: nausea, upset stomach, loss of appetite, and dizziness. This chemical's classification codes are Anti-infective Agents; Antibacterial; Antiparasitic Agents; Antiprotozoal agents; Coccidiostats; Drug / Therapeutic Agent; Human Data; Reproductive Effect.

Physical properties of Sulfadiazine: (1)ACD/LogP: -0.12; (2)ACD/LogD (pH 5.5): -0.13; (3)ACD/LogD (pH 7.4): -0.66; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 19.93; (7)ACD/KOC (pH 7.4): 5.87; (8)#H bond acceptors: 6; (9)#H bond donors: 3; (10)#Freely Rotating Bonds: 2; (11)Index of Refraction: 1.679; (12)Molar Refractivity: 63.14 cm3; (13)Molar Volume: 167.2 cm3; (14)Surface Tension: 82.6 dyne/cm; (15)Density: 1.496 g/cm3; (16)Flash Point: 263.8 °C; (17)Enthalpy of Vaporization: 78.38 kJ/mol; (18)Boiling Point: 512.6 °C at 760 mmHg; (19)Vapour Pressure: 1.28E-10 mmHg at 25°C.

Preparation of Sulfadiazine: this chemical can be prepared by chaff iodate and nitro metformin. This reaction will need reagents acetyl groups benzene sulfo-chloride and pyridine.

Uses of Sulfadiazine: It eliminates bacteria that cause infections by stopping the production of folic acid inside the bacterial cell, and is commonly used to treat urinary tract infections (UTIs). In combination, sulfadiazine and pyrimethamine, can be used to treat toxoplasmosis, a disease caused by Toxoplasma gondii.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
(2)InChI: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,; (3)16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
(4)InChIKey: SEEPANYCNGTZFQ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 1800mg/kg/5D- (1800mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: HEMATURIA

ENDOCRINE: HYPOGLYCEMIA
Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977.
child TDLo unreported 138mg/kg (138mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

KIDNEY, URETER, AND BLADDER: HEMATURIA

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Postgraduate Medical Journal. Vol. 53, Pg. 103, 1977.
dog LD oral > 5gm/kg (5000mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 79, Pg. 354, 1943.
man TDLo oral 229mg/kg/8D-I (229mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
Israel Journal of Medical Sciences. Vol. 6, Pg. 561, 1970.
mouse LD50 intraperitoneal 750mg/kg (750mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 109, 1969.
mouse LD50 intravenous 180mg/kg (180mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#03347,
mouse LD50 oral 1500mg/kg (1500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 21, Pg. 571, 1971.
mouse LD50 subcutaneous 1600mg/kg (1600mg/kg)   Drugs in Japan Vol. 6, Pg. 386, 1982.
rat LD50 intravenous 880mg/kg (880mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 211, Pg. 367, 1950.
rat LDLo intraperitoneal 446mg/kg (446mg/kg)   Klinische Wochenscrift. Vol. 27, Pg. 449, 1949

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 68-35-9