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TETRAETHYL PYROPHOSPHATE
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TETRAETHYL PYROPHOSPHATE

 EINECS 203-495-3
CAS No. 107-49-3 Density 1.205 g/cm3
PSA 99.91000 LogP 3.36520
Solubility Miscible Melting Point 208-213℃ (decomposition)
Formula C8H20 O7 P2 Boiling Point 260.9 °C at 760 mmHg
Molecular Weight 290.19 Flash Point 125.6 °C
Transport Information N/A Appearance N/A
Safety Human poison by ingestion and intramuscular routes. Experimental poison by ingestion, skin contact, intraperitoneal, intramuscular, subcutaneous, parenteral, and intravenous routes. Human systemic effects by ingestion, intramuscular, and parenteral routes: paresthesia, wakefulness, excitement, muscle contraction or spasticity, nausea or vomiting and other gastrointestinal changes. The action is similar to that of parathion: causing an irreversible inhibition of the cholinesterase molecules and the consequent accumulation of large amounts of acetylcholine. Small doses at frequent intervals are largely additive. When heated to decomposition it emits toxic fumes of POx. See also PARATHION.

Analytical Methods:

   

For occupational chemical analysis use NIOSH: Tetraethyl Pyrophosphate, 2504.

Risk Codes 27/28-50
Molecular Structure Molecular Structure of 107-49-3 (TEPP) Hazard Symbols Toxic by skin contact, inhalation, or ingestion; rapidly absorbed through skin; repeated exposure may, without symptoms, be increasingly hazardous; cholinesterase inhibitor, use may be restricted. TLV: 0.004 ppm. Toxic by skin absorption.
Synonyms

Diphosphoricacid, tetraethyl ester (9CI); Pyrophosphoric acid, tetraethyl ester (8CI);Bis-O,O-diethylphosphoric anhydride; Bladan; Ethyl pyrophosphate (Et4P2O7);Killex; NSC 14707; NSC 646213; Nifos; Pyrodust; TEP; TEP (phosphate); TEPP;Tetraethyl diphosphate; Tetraethyl pyrophosphate; Tetrastigmine; Vapotone

Article Data 115

TETRAETHYL PYROPHOSPHATE Chemical Properties

IUPAC Name: Diethoxyphosphoryl diethyl phosphate
Synonyms: Mortopal(r) ; Nifos t(r) ; O,O-Tepp ; Tepp ; Tetron ; Tetraethylpyrophosphate ; Tetraethyl diphosphate ; Vapotone(R)
CAS: 107-49-3
Molecular Formula: C8H20O7P2
Molecular Weight: 290.19
Molecular Struture:  
EINECS: 203-495-3
Mol File: 107-49-3.mol
Surface Tension: 36.8 dyne/cm 
Density: 1.205 g/cm3 
Flash Point: 125.6 °C 
Enthalpy of Vaporization: 47.85 kJ/mol 
Boiling Point: 260.9 °C at 760 mmHg 
Vapour Pressure: 0.0193 mmHg at 25°C 
Storage temp:  2-8°C
Merck : 13,9279
Appearance: Tetraethyl pyrophosphate (107-49-3) is water-white to amber liquid, depending on purity.

TETRAETHYL PYROPHOSPHATE Toxicity Data With Reference

1.    

par-hmn TDLo:71 µg/kg:CNS,GIT

     CMEP**    Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1.
2.    

orl-hmn LDLo:1429 µg/kg:PNS,CNS,GIT

     CMEP**    Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1.
3.    

orl-hmn TDLo:309 µg/kg:CNS,GIT

     CMEP**    Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1.
4.    

ims-hmn LDLo:286 µg/kg:PNS,CNS,GIT

     CMEP**    Clinical Memoranda on Economic Poisons US Dept. HEW, Public Health Service, Communicable Disease Center,Atlanta, GA.: 1956,1.
5.    

orl-rat LD50:500 µg/kg

     PHJOAV    Pharmaceutical Journal. 185 (1960),361.
6.    

skn-rat LD50:2400 µg/kg

     TXAPA9    Toxicology and Applied Pharmacology. 14 (1969),515.
7.    

ipr-rat LD50:650 µg/kg

     FEPRA7    Federation Proceedings, Federation of American Societies for Experimental Biology. 6 (1947),353.
8.    

scu-rat LD50:279 µg/kg

     FAATDF    Fundamental and Applied Toxicology. 4 (2,Pt 2),(1984),S195.
9.    

ivn-rat LD50:300 µg/kg

     CJBPAZ

TETRAETHYL PYROPHOSPHATE Consensus Reports

EPA Extremely Hazardous Substances List.

TETRAETHYL PYROPHOSPHATE Safety Profile

Hazard Codes  T+,N
Risk Statements  27/28-50
50:  Tetraethyl pyrophosphate (107-49-3) isvery Toxic to aquatic organisms 
27/28:  Very Toxic in contact with skin and if swallowed 
Safety Statements  36/37/39-38-45-61
38:  In case of insufficient ventilation, wear suitable respiratory equipment 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) 
61:  Avoid release to the environment. Refer to special instructions safety data sheet 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection  
RIDADR  3018
RTECS  UX6825000
HazardClass  6.1(a)
PackingGroup  I

TETRAETHYL PYROPHOSPHATE Standards and Recommendations

OSHA PEL: TWA 0.05 mg/m3 (skin)
ACGIH TLV: TWA 0.004 mg/m3 (skin)
DFG MAK: 0.005 ppm (0.060 mg/m3)
DOT Classification:  6.1; Label: Poison

TETRAETHYL PYROPHOSPHATE Analytical Methods

For occupational chemical analysis use NIOSH: Tetraethyl Pyrophosphate, 2504.

TETRAETHYL PYROPHOSPHATE Specification

1.Air & Water: Reactions Hygroscopic. Hydrolyzed in water with formation of mono. di, and triethyl orthophosphates, water solutions attack metal surfaces. Reacts slowly with water to form phosphoric acid
2.Reactivity Profile: Organophosphates, such as Tetraethyl pyrophosphate (107-49-3) , are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
3.Health Hazard :Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
4.Fire Hazard :Combustible material: may burn but does not ignite readily. Containers may explode when heated. Runoff may pollute waterways. Substance may be transported in a molten form.
 

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