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TIQUIZIUM BROMIDE

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Name TIQUIZIUM BROMIDE EINECS
CAS No. 71731-58-3 Density
Solubility Melting Point
Formula C19H24 N S2 . Br Boiling Point
Molecular Weight 410.47 Flash Point
Transport Information Appearance
Safety Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br, NOx, and SOx. Risk Codes
Molecular Structure Molecular Structure of 71731-58-3 (2H-Quinolizinium,3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide (1:1), (5R,9aR)-rel-) Hazard Symbols
Synonyms

2H-Quinolizinium,3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, (5R,9aR)-rel- (9CI);2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide,trans-; HS 902; HSR 902; Thiaton; Tiquizium bromide

 

Chemistry

IUPAC Name:(5R,9aR)-7-(dithiophen-2-ylmethylidene)-5-methyl-1,2,3,4,6,8,9,9a-
octahydroquinolizin-5-ium bromide(71731-58-3)
Synonyms: Tiquizium bromide ; (5R,9aR)-7-(dithiophen-2-ylmethylidene)-5-methyl-1,2,3,4,6,8,9,9a-octahydroquinolizin-5-ium bromide ; Tiquizium ; 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, (5R,9aR)-rel- (9CI) ; 2H-Quinolizinium, 3-(di-2-thienylmethylene)octahydro-5-methyl-, bromide, trans- ; HS 902;HSR 902 ; Thiaton
CAS:71731-58-3 
MF: C19H24BrNS2
MW: 410.43 
Mol File: 71731-58-3.mol
Melting point :246 ~ 248 ℃
Appearance: Tiquizium bromide (71731-58-3) is prism crystals.

Uses

1.Tiquizium bromide (71731-58-3) is antispasmodic, which can be obtained   from 2 - hydroxyethyl-pyridine of the raw material;
2.Tiquizium bromide (71731-58-3) have good effects on spasm, gastric secretion inhibition and anti-ulcer caused by anti-acetylcholine of parasympathetic nerve endings.
 

Toxicity Data With Reference

Organism

Test Type

Route

Reported Dose (Normalized Dose)

Effect

Source

dog

ld50

intraperitoneal

56700ug/kg (56.7mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

dog

ld50

intravenous

14200ug/kg (14.2mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

dog

ld50

oral

662mg/kg (662mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

dog

ld50

subcutaneous

129mg/kg (129mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
lungs, thorax, or respiration: dyspnea
behavioral: convulsions or effect on seizure threshold

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

mouse

ld50

intraperitoneal

83700ug/kg (83.7mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

mouse

ld50

intravenous

10300ug/kg (10.3mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
lungs, thorax, or respiration: dyspnea
behavioral: convulsions or effect on seizure threshold

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

mouse

ld50

oral

578mg/kg (578mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

mouse

ld50

subcutaneous

82100ug/kg (82.1mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
lungs, thorax, or respiration: dyspnea
behavioral: convulsions or effect on seizure threshold

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

rat

ld50

intraperitoneal

70500ug/kg (70.5mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

rat

ld50

intravenous

11400ug/kg (11.4mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold

lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

rat

ld50

oral

1177mg/kg (1177mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

rat

ld50

subcutaneous

169mg/kg (169mg/kg)

sense organs and special senses: mydriasis (pupillary dilation): eye
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: dyspnea

oyo yakuri. pharmacometrics. vol. 23, pg. 1, 1982.

 

Safety Profile

Poison by subcutaneous, intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Br, NOx, and SOx.

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