Basic information
- Name:
Tacrolimus monohydrate
- CAS No.:
109581-93-3
- Molecular Structure:
- Formula:
- C44H69NO12.H2O
- Molecular Weight:
- 822.16
- Synonyms:
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)- (9CI);15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,monohydrate,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;Tsukubaenolide hydrate;
- Boiling Point:
- 871.7 °C at 760 mmHg
- Flash Point:
- 481 °C
- Hazard Symbols:
T- Risk Codes:
- 25
- Safety Description:
- 45 Details
- Transport Information:
- UN 2811 6.1/PG 3
Famous Chemical Enterprises
-
Livzon -
Total -
Shell -
Dupont -
Exxonmobil -
Akzonobel -
Basf -
Bayer -
BP
Please post your buying leads,so that our qualified suppliers will soon
contact you!
*Required Fields
Chemistry
Molecular Formula: C44H69NO12.H2O
Molecular Weight: 822.03
Flash Point: 481 °C
Storage tempreture: -20 °C
Enthalpy of Vaporization: 143.95 kJ/mol
Boiling Point: 871.7 °C at 760 mmHg
Vapour Pressure: 1.73E-35 mmHg at 25 °C
Structure of Tacrolimus monohydrate (CAS NO.109581-93-3):
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| rat | LD50 | intravenous | 23600ug/kg (23.6mg/kg) | Drugs in Japan Vol. -, Pg. 720, 1995. | |
| rat | LD50 | oral | 134mg/kg (134mg/kg) | Drugs in Japan Vol. -, Pg. 720, 1995. |
Safety Profile
Hazard Codes of Tacrolimus monohydrate (CAS NO.109581-93-3): T .gif){kind=small}
Risk Statements: 25
R25 :Toxic if swallowed.
Safety Statements: 45
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
Specification
Tacrolimus monohydrate , its cas register number is 109581-93-3. It also can be called Prograf ; Fk-506 ; and Tacrolimus . Tacrolimus monohydrate (CAS NO.109581-93-3) reduces myasthenic symptoms due to its immunosuppressive properties. We studied its therapeutic effects and noted improvement in 7 of 13 myasthenic patients on the clinical muscle test. Two other patients with relapsing ocular symptoms improved. We also examined patient sensitivity to FK506, but could not predict such sensitivity before it treatment in the present study.