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Telatinib
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Name

Telatinib

 EINECS N/A
CAS No. 332012-40-5 Density 1.418 g/cm3
PSA 102.17000 LogP 4.41730
Solubility N/A Melting Point N/A
Formula C20H16ClN5O3 Boiling Point 713.595 °C at 760 mmHg
Molecular Weight 409.832 Flash Point 385.368 °C
Transport Information N/A Appearance N/A
Safety Risk Codes N/A
Molecular Structure Molecular Structure of 332012-40-5 (Telatinib) Hazard Symbols N/A
Synonyms

Bay57-9352;Telatinib [INN];4-[[4-(4-Chloroanilino)furo[2,3-d]pyridazin-7-yl]oxymethyl]-N-methylpyridine-2-carboxamide;BAY-579352;2-Pyridinecarboxamide,4-[[[4-[(4-chlorophenyl)amino]furo[2,3-d]pyridazin-7-yl]oxy]methyl]-N-methyl-;UNII-18P7197Q7J;

Article Data 4

Telatinib Synthetic route

332013-43-1

4-(hydroxymethyl)-N-methylpyridine-2-carboxamide

332013-40-8

4-chloroanilino-7-chlorofuro[2,3-d]pyridazine

332012-40-5

Telatinib

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether In toluene at 83 - 87℃; Product distribution / selectivity;46%
With potassium hydroxide; 18-crown-6 ether In toluene at 20 - 85℃;46%
332013-43-1

4-(hydroxymethyl)-N-methylpyridine-2-carboxamide

332013-41-9

4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine

332012-40-5

Telatinib

Conditions
ConditionsYield
With potassium hydroxide; 18-crown-6 ether In toluene at 20 - 87℃; Product distribution / selectivity;46%
Stage #1: 4-(hydroxymethyl)-N-methylpyridine-2-carboxamide; 4-chloro-7-[N-(4-chlorophenyl)amino]-[2,3-d]furopyridazine; 18-crown-6 ether In toluene at 20℃; for 0.166667h;
Stage #2: With potassium hydroxide In toluene at 80℃; for 24h; Product distribution / selectivity;
332013-40-8

4-chloroanilino-7-chlorofuro[2,3-d]pyridazine

1182334-19-5

2-methylaminocarbonyl-4-pyridylcarbinol hydrochloride

332012-40-5

Telatinib

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran; toluene at 95℃; for 24h; Temperature; Time; Autoclave;37.7%
123-39-7

N-Methylformamide

N-(4-chlorophenyl)-7-(4-pyridinylmethoxy)-furo[2,3-d]pyridazin-4-amine

A

332012-40-5

Telatinib

B

332012-41-6

4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine

Conditions
ConditionsYield
With sulfuric acid; hydroxylamine-O-sulfonic acid; iron(II) sulfate In water at 20℃; for 1.83333h; Product distribution / selectivity;A 15.2%
B n/a
Stage #1: N-Methylformamide; N-(4-chlorophenyl)-7-(4-pyridinylmethoxy)-furo[2,3-d]pyridazin-4-amine With sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid In water at 20℃; for 1.83333h;
Stage #2: With sodium citrate In water at 0℃; for 0.166667h; Product distribution / selectivity;		A 15.2%
B n/a
With sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid In water at 20℃; for 1.66667h;A 15.2%
B n/a
332013-42-0

ethyl 2-methylaminocarbonyl-4-picolinate

332012-40-5

Telatinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / isopropyl alcohol; methanol / 8 h / 25 °C / Large scale
1.2: 1 h / 0 °C / Large scale
2.1: potassium tert-butylate / toluene; tetrahydrofuran / 24 h / 95 °C / Autoclave
View Scheme
Multi-step reaction with 2 steps
1.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C
1.3: pH 9
2.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C
View Scheme
Multi-step reaction with 2 steps
1: sodium tetrahydroborate / ethanol / 18 h / 20 °C
2: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C
View Scheme
13177-70-3

4,7-dichlorofuro[2,3-d]pyridazine

332012-40-5

Telatinib

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 4 h / Heating / reflux
2: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C
View Scheme
Multi-step reaction with 2 steps
1: ethanol / 4 h / Heating / reflux
2: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C
View Scheme
13177-70-3

4,7-dichlorofuro[2,3-d]pyridazine

A

332012-40-5

Telatinib

B

332012-41-6

4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: ethanol / 4 h / Heating / reflux
2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C
3.1: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.83 h / 20 °C
3.2: 0.17 h / 0 °C
View Scheme
Multi-step reaction with 3 steps
1: ethanol / 4 h / Heating / reflux
2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C
3: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.67 h / 20 °C
View Scheme
1570-45-2

isonicotinic acid ethylester

332012-40-5

Telatinib

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.5 h / 6 - 22 °C
1.2: pH ~ 5
2.1: sodium tetrahydroborate / ethanol / 18 h / 20 °C
2.3: pH 9
3.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C
View Scheme
Multi-step reaction with 3 steps
1: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.5 h / 6 - 22 °C
2: sodium tetrahydroborate / ethanol / 18 h / 20 °C
3: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C
View Scheme
4282-24-0

furan-2,3-dicarboxylic acid

332012-40-5

Telatinib

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: chloro-trimethyl-silane / 15.5 h / 20 °C
2.1: ethanol; water; hydrazine / 5.5 h / Heating / reflux
2.2: 4 h / Heating / reflux
3.1: pyridine; trichlorophosphate / 4 h / Heating / reflux
4.1: ethanol / 4 h / Heating / reflux
5.1: potassium hydroxide; 18-crown-6 ether / toluene / 83 - 87 °C
View Scheme
Multi-step reaction with 5 steps
1: chloro-trimethyl-silane / 15.5 h / 20 °C
2: hydrazine / ethanol / 5.5 h / Heating / reflux
3: pyridine; trichlorophosphate / 4 h / Heating / reflux
4: ethanol / 4 h / Heating / reflux
5: potassium hydroxide; 18-crown-6 ether / toluene / 20 - 85 °C
View Scheme
4282-24-0

furan-2,3-dicarboxylic acid

A

332012-40-5

Telatinib

B

332012-41-6

4-(4-chlorophenylamino)-2-methylaminocarbonyl-7-(2-methylaminocarbonyl-4-pyridylmethoxy)-furo[2,3-d]pyridazine

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: chloro-trimethyl-silane / 15.5 h / 20 °C
2.1: ethanol; water; hydrazine / 5.5 h / Heating / reflux
2.2: 4 h / Heating / reflux
3.1: pyridine; trichlorophosphate / 4 h / Heating / reflux
4.1: ethanol / 4 h / Heating / reflux
5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C
6.1: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.83 h / 20 °C
6.2: 0.17 h / 0 °C
View Scheme
Multi-step reaction with 6 steps
1: chloro-trimethyl-silane / 15.5 h / 20 °C
2: hydrazine / ethanol / 5.5 h / Heating / reflux
3: pyridine; trichlorophosphate / 4 h / Heating / reflux
4: ethanol / 4 h / Heating / reflux
5: 1,8-diazabicyclo[5.4.0]undec-7-ene / 24 h / 125 °C
6: sulfuric acid; iron(II) sulfate; hydroxylamine-O-sulfonic acid / water / 1.67 h / 20 °C
View Scheme

Telatinib Chemical Properties

IUPAC Name: [(8Z,12Z,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12, 14,18-pentaen-10-yl] carbamate
Molecular Formula: C31H43N3O8
Molecular Weight: 585.69g/mol
Density: 1.21
Melting Point: 201-203°C 
The Cas Register Number of Telatinib is 75747-14-7 .The chemical synonyms of Telatinib  (CAS NO. 75747-14-7) are Geldanamycin,17-demethoxy-17-(2-propenylamino)- ; CP 127374 ; Allylaminogeldanamycin ; 17-(Allylamino)-17-demethoxygeldanamycin ; 17-(Allylamino)-17-desmethoxygeldanamycin ; 17-(Allylamino)-17-dimethoxygeldanamycin ; 17-Allylaminogeldanamycin ; 17-AG .The molecular structure of  Telatinib (CAS NO. 75747-14-7) is.

Telatinib Uses

 It is a substance that is being studied in the treatment of cancer, specific young patients with certain types of leukemia or solid tumors, especially kidney tumors.

Telatinib Safety Profile

Hazard Codes:IrritantXi
Risk Statements: 36/37/38 
R36: Irritating to eyes. 
R37: Irritating to respiratory system 
R38: Irritating to skin. 
Safety Statements: 22-24/25-36-26
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes. 
S36: Wear suitable protective clothing. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3

Telatinib Specification

The extinguishing agent of Telatinib (CAS NO. 75747-14-7) are dry powder, foam, sand, carbon dioxide, water mist.

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