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Basic information

  • Name:
  • Telmisartan

  • CAS No.:
  • 144701-48-4

  • Formula:
  • C33H30N4O2
  • Synonyms:
  • (1,1-Biphenyl)-2-carboxylic acid, 4-((1,4-dimethyl-2-propyl(2,6-bi-1H-benzimidazol)-1-yl)methyl)-;Micardis;4-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid;Timetazidine;4'-[(1,4'-dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]- [1,1'-biphenyl]-2-carboxylic acid;
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Chemistry

IUPAC Name: 2-[4-[[4-Methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid
Synonyms of Telmisartan (CAS NO.144701-48-4): 4'[(1,4'-Dimethyl-2'-propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid
CAS NO: 144701-48-4
Molecular Formula: C33H30N4O2
Molecular Weight: 514.62
Molecular Structure: 
H bond acceptors: 6
H bond donors: 1
Freely Rotating Bonds: 7
Polar Surface Area: 61.94 Å2
Index of Refraction: 1.667
Molar Refractivity: 154.51 cm3
Molar Volume: 414.9 cm3
Surface Tension: 48.7 dyne/cm
Density: 1.24 g/cm3
Flash Point: 420.6 °C
Enthalpy of Vaporization: 117.87 kJ/mol
Boiling Point: 771.9 °C at 760 mmHg
Vapour Pressure: 4.58E-25 mmHg at 25°C 
Melting Point: 261-263°C
Solubility: DMSO: >5 mg/mL at 60 °C
Water Solubility: insoluble
Appearance: White or off white crystalline powder 
Product Categories of Telmisartan (CAS NO.144701-48-4): Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;INTERMEDIATESOF;Antihypertensive;Imidazoles;(intermediates of telmisartan);Telmisartan;Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;API's

Uses

 Telmisartan (CAS NO.144701-48-4) is an angiotensin II receptor antagonist used in the management of hypertension.

Consensus Reports

It is believed that telmisartan’s dual mode of action may provide protective benefits against the vascular and renal damage caused by diabetes and cardiovascular disease (CVD).

Safety Profile

Safety Information about Telmisartan (CAS NO.144701-48-4):
Hazard Codes: IrritantXi
Risk Statements: 36/37/38 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36-26 
S22: Do not breathe dust. 
S24/25: Avoid contact with skin and eyes. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36: Wear suitable protective clothing.
WGK Germany: 2

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