Basic information
- Name:
Tetramethyl ammonium chloride
- CAS No.:
75-57-0
- Molecular Structure:
- Formula:
- C4H12NCl
- Molecular Weight:
- 109.62
- Deleted CAS:
- 79098-37-6|251459-49-1
- Synonyms:
- Ammonium,tetramethyl-, chloride (8CI);Methanaminium, N,N,N-trimethyl-, chloride (9CI);Tetramethylammonium chloride (6CI);Tetramine chloride;
- EINECS:
- 200-880-8
- Density:
- 1.17 g/cm3
- Melting Point:
- >300 °C(lit.)
- Solubility:
- >60 g/100 mL (20 °C ) in water
- Appearance:
- white crystals
- Hazard Symbols:
T, 
Xn- Risk Codes:
- 21-25-36/37/38-20/21/22
- Safety Description:
- 26-36/37-45-37/39-28A-28-36 Details
- Transport Information:
- UN 2811 6.1/PG 2
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Chemistry
Molecular Structure of Tetramethyl ammonium chloride (CAS NO.75-57-0):
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IUPAC Name: tetramethylazanium chloride
Empirical Formula: C4H12ClN
Molecular Weight: 109.5978
CAS Registry Number: 75-57-0
EINECS: 200-880-8
H bond acceptors: 1
H bond donors: 0
Freely Rotating Bonds: 0
Polar Surface Area: 0 Å2
Melting point: 420 °C
Density: 1,17 g/cm3
Water solubility: >60 g/100 mL (20 °C )
Storage temp: Store at RT
Sensitive: Hygroscopic
BRN: 2496575
Stability: Stable. Incompatible with strong oxidizing agents, water. Hygroscopic
Product Categories: quarternary ammonium salts; Ammonium Chlorides (Quaternary); Quaternary Ammonium Compounds; Ammonium SaltsNucleic Acid Detection and Hybridization; Greener Alternatives; Catalysis; Hybridization Kits and Reagents; Phase Transfer Catalysts; Reagents for Hybridization
InChI
InChI=1/C4H12N.ClH/c1-5(2,3)4;/h1-4H3;1H/q+1;/p-1
Smiles
[N+](C)(C)(C)C.[ClH-]
Toxicity Data With Reference
| 1. | orl-mus LDLo:125 mg/kg | JPMSAE Journal of Pharmaceutical Sciences. 69 (1980),327. | ||
| 2. | ipr-mus LD50:25 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) AD414-344 . | ||
| 3. | scu-mus LD50:40 mg/kg | NTIS** National Technical Information Service. (Springfield, VA 22161) (Formerly U.S. Clearinghouse for Scientific and Technical Information) ORNL-5576 . | ||
| 4. | scu-rbt LDLo:6 mg/kg | AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. 7 (1900),183. | ||
| 5. | scu-frg LDLo:2 mg/kg | SAPHAO Skandinavisches Archiv fuer Physiologic. 10 (1900),201. |
Consensus Reports
Reported in EPA TSCA Inventory.
Safety Profile
Poison by ingestion, intraperitoneal, and subcutaneous routes. When heated to decomposition it emits very toxic fumes of NOx, NH3, and Cl−. See also CHLORIDES.
Hazard Codes: 
T,
Xn
Risk Statements: 21-25-36/37/38-20/21/22
R21:Harmful in contact with skin.
R25 :Toxic if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-36/37-45-37/39-28A-28-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S37/39:Wear suitable gloves and eye/face protection.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 1
RTECS: BS7700000
F: 3-10
HazardClass: 6.1
PackingGroup: II
HS Code: 29239000
Specification
Tetramethyl ammonium chloride , with CAS number of 75-57-0, can be called methanaminium, N,N,N-trimethyl-, chloride (1:1) ; N,N,N-Trimethylmethanaminium chloride ; TMAC . It is a white crystal. Tetramethyl ammonium chloride (CAS NO.75-57-0) is used as a phase transfer catalyst for anionic reactants. In small concentrations, also has been shown to enhance yield 5-10 fold at 3M by stabilizing the AT base pairs. Besidea used with polymerase chain reactions to increase yield and specificity.