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Cas Database |
| Name |
Tiamulin |
EINECS | 259-580-0 |
| CAS No. | 55297-95-5 | Density | 1.1 g/cm3 |
| PSA | 92.14000 | LogP | 4.96790 |
| Solubility | N/A | Melting Point |
147-148oC |
| Formula | C28H47NO4S | Boiling Point | 563 °C at 760 mmHg |
| Molecular Weight | 493.751 | Flash Point | 294.3 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Aceticacid, [[2-(diethylamino)ethyl]thio]-,(3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester (9CI);Acetic acid, [[2-(diethylamino)ethyl]thio]-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester, [3aS-(3aa,4b,5a,6a,8b,9a,9ab,10S*)]-;Denagard;Thiamutilin;Tiavet P;Acetic acid,2-[[2-(diethylamino)ethyl]thio]-,(3aS,4R,5S,6S,8R,9S,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-ylester; |
Article Data | 4 |
Tiamulin Specification
1. Introduction of Tiamulin
Tiamulin (55297-95-5), with chemical name of (1S,2R,3S,4S,6R,7S,14R)-6-[(2-Diethylaminoethylthio)acetoxy]-3-hydroxy-2,4,7,14-tetramethyl-4-vinyltricyclo[5,4,3,01.8]tetradecan-9-one, is white to pale yellow crystalline powder. It is soluble in water, 1:16.6, which is stable in the dry powder, not stable to light and heat.
2. Properties of Tiamulin
Tiamulin has the following properties: (1)Surface Tension: 44.8 dyne/cm; (2)Density: 1.1 g/cm3; (3)Flash Point: 294.3 °C; (4)Enthalpy of Vaporization: 97.23 kJ/mol; (5)Boiling Point: 563 °C at 760 mmHg; (6)Vapour Pressure: 5.06E-15 mmHg at 25°C.
3. Structure Descriptors of Tiamulin
You could convert the following datas into the molecular structure:
4. Toxicity of Tiamulin
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| chicken | LD50 | intramuscular | 250mg/kg (250mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| chicken | LD50 | intravenous | 25mg/kg (25mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| chicken | LD50 | oral | 1550mg/kg (1550mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| mammal (species unspecified) | LD50 | oral | 812mg/kg (812mg/kg) | Drugs of the Future. Vol. 2, Pg. 274, 1977. | |
| mouse | LD50 | intravenous | 49mg/kg (49mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| mouse | LD50 | oral | 710mg/kg (710mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| mouse | LD50 | subcutaneous | 1020mg/kg (1020mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| rat | LD50 | intravenous | 20mg/kg (20mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| rat | LD50 | oral | 2230mg/kg (2230mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| rat | LD50 | subcutaneous | 4380mg/kg (4380mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| turkey | LD50 | intramuscular | 409mg/kg (409mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. | |
| turkey | LD50 | oral | 1345mg/kg (1345mg/kg) | Rivista di Zootecnia e Veterinaria. Zootechnical and Veterinary Review. Vol. 8, Pg. 251, 1980. |
5. Use of Tiamulin
1) Tiamulin is a relatively new type of antibiotic, which is an animal-specific antibiotic.
2).It has a have special effects on number of Gram-positive bacteria and mycoplasma (Mycoplasma) ,
3).by far, Tiamulin is the most effective antibiotics against the Mycoplasma gallisepticum on the chicken , maintain high concentrations on respiratory tract on which Mycoplasma breeding.
4).Especially have a strong effect against Staphylococcus aureus, Streptococcus, a variety of mycoplasma and some spirochetes .
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