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Cas Database |
| Name |
Tienilic acid |
EINECS | N/A |
| CAS No. | 40180-04-9 | Density | 1.532 |
| PSA | 91.84000 | LogP | 3.74930 |
| Solubility | N/A | Melting Point |
148-149oC |
| Formula | C13H8Cl2O4S | Boiling Point | 534.6°C at 760 mmHg |
| Molecular Weight | 331.176 | Flash Point | 277.1°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, kidney damage and decreased urine volume or anuria. Mutation data reported. Used as a diuretic, uricosuric and antihypertensive. When heated to decomposition it emits toxic fumes of Cl− and SOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Tienilic acid;Tienilico acido;Acidum tienilicum;TienilicAcid;Selacryn;Diflurex;Ticrynafen Tienylic acid [2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy]-acetic acid;[2,3-dichloro-4-(2-thenoyl)phenoxy]acetic acid;Acido tienilico;Acide tienilique;2,3-dichloro-4-(thien-2-ylcarbonyl)-phenoxyacetic acid;[2,3-dichloro-4-(thiophene-2-carbonyl)-phenoxy]-acetic acid;Ticrex;Ticrynafen;2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid;Thienylic acid; |
Article Data | 4 |
Tienilic acid Chemical Properties
Product Name: Tienilic acid (CAS NO.40180-04-9)
Molecular Formula: C13H8Cl2O4S
Molecular Weight: 331.1712g/mol
Mol File: 40180-04-9.mol
Boiling point: 534.6 °C at 760 mmHg
Flash Point: 277.1 °C
Density: 1.532 g/cm3
Surface Tension: 59.4 dyne/cm
Enthalpy of Vaporization: 85.34 kJ/mol
Vapour Pressure: 2.94E-12 mmHg at 25°C
XLogP3-AA: 4.1
H-Bond Donor: 1
H-Bond Acceptor: 4
Tienilic acid Uses
Tienilic acid (CAS NO.40180-04-9) (INN and BAN) or ticrynafen (USAN) is a diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was withdrawn in 1982, shortly after its introduction to the market, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis.
Tienilic acid Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 3571ug/kg (3.571mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | Clinical Toxicology. Vol. 18, Pg. 425, 1981. |
| man | TDLo | oral | 6666ug/kg (6.666mg/kg) | KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | New England Journal of Medicine. Vol. 301, Pg. 1180, 1979. |
| mouse | LD50 | intraperitoneal | 318mg/kg (318mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Drugs of the Future. Vol. 13, Pg. 257, 1988. |
| mouse | LD50 | intravenous | 225mg/kg (225mg/kg) | United States Patent Document. Vol. #3758506, | |
| mouse | LD50 | oral | 1275mg/kg (1275mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 9, Pg. 625, 1974. | |
| women | TDLo | oral | 5mg/kg (5mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED | New England Journal of Medicine. Vol. 301, Pg. 1179, 1979. |
Tienilic acid Safety Profile
Poison by intravenous route. Moderately toxic by ingestion. Human systemic effects by ingestion: nausea or vomiting, kidney damage and decreased urine volume or anuria. Mutation data reported. Used as a diuretic, uricosuric and antihypertensive. When heated to decomposition it emits toxic fumes of Cl− and SOx.
Tienilic acid Specification
Tienilic acid ,its CAS NO. is 40180-04-9,the synonyms is (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid
(2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid ; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid ; 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure ; 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid ; 5-18-02-00008 (Beilstein Handbook Reference) ; ANP 3624 ; Acetic acid, (2,3-dichloro-4-(2-thienylcarbonyl)phenoxy)- ; Acide tienilique ; Acidum tienilicum ; Selacryn ; Ticrex ; Ticrynafen .
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