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Tolperisone

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Name

Tolperisone

EINECS 211-976-4
CAS No. 728-88-1 Density 1.004g/cm3
PSA 20.31000 LogP 3.23760
Solubility N/A Melting Point 176.5°C
Formula C16H23 N O Boiling Point 373.9°C at 760 mmHg
Molecular Weight 245.365 Flash Point 134.4°C
Transport Information N/A Appearance N/A
Safety Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx. Risk Codes N/A
Molecular Structure Molecular Structure of 728-88-1 (Tolperisone) Hazard Symbols N/A
Synonyms

Propiophenone,2,4'-dimethyl-3-piperidino- (7CI,8CI); (?à)-Tolperisone; 2,4'-Dimethyl-3-piperidinopropiophenone;Mideton; Mydeton; Mydetone; NSC 107321; Tolperisone; dl-Tolperisone

Article Data 3

Tolperisone Chemical Properties

IUPAC Name:  2-Methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one
The MF of Tolperisone (CAS NO.728-88-1) is C16H23NO.

                    
The MW of Tolperisone (CAS NO.728-88-1) is 245.36.
Synonyms of Tolperisone (CAS NO.728-88-1): 1-Piperidino-2-methyl-3-(p-tolyl)-3-propanone ; 2,4'-Dimethyl-3-piperidino-propiophenon ; 2-Methyl-3-piperidino-1-p-tolylpropan-1-one ; 1-Propanone, 2-methyl-1-(4-methylphenyl)-3-(1-piperidinyl)-(9CI)
Index of Refraction: 1.526 
EINECS: 211-976-4
Density: 1.004 g/ml 
Flash Point: 134.4 °C
Boiling Point: 373.9 °C

Tolperisone Uses

Typically, Tolperisone (CAS NO.728-88-1) is indicated in the treatment of acute muscle spasms in back pain and spasticity in neurological diseases.

Tolperisone Toxicity Data With Reference

1.    

orl-rat LD50:1450 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),421.
2.    

ipr-rat LD50:170 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),421.
3.    

scu-rat LD50:645 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),421.
4.    

orl-mus LD50:1350 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),421.
5.    

scu-mus LD50:620 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 11 (1961),257.
6.    

ivn-mus LD50:34 mg/kg

    OYYAA2    Oyo Yakuri. Pharmacometrics. 5 (1971),421.

Tolperisone Safety Profile

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.

Tolperisone Specification

 Tolperisone, a piperidine derivative, is a centrally acting muscle relaxant. Brand names include Mydocalm and Mydeton.
 Tolperisone is currently marketed in Europe as a centrally-acting muscle relaxant which reportedly has special advantages over other drugs of its class in that it is reported not to cause drowsiness or lethargy according to some manufacturers.
 Besides claiming that "Tolperisone has an excellent efficacy & safety profile" these manufacturers also state that Tolperisone has the unique property of mediating muscle relaxation without concomitant sedation nor does it cause impairment of coordination, weakness, mental confusion or withdrawal phenomena in contrast to other muscle relaxants.
 Some people using Tolperisone have reported the following reactions:In hypersensitivity: muscle weakness, headache, arterial hypotension, nausea, vomiting, dyspepsia.Skin allergic reactions: skin rash, hives, Quincke's edema, anaphylactic shock.
 The side effects and reactions listed above may not include all effects reported by the drug's manufacturer.
It is believed that Tolperisone has few interactions with other medicines. However, this doesn't rule out any interactions that may or may not have been reported to care-givers thus far.Some manufacturers have stated that Tolperisone may enhance the effects of other neuromuscular blocking agents.

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