Basic information
- Name:
Cyclohexanol,2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1R,2R)-rel-
- Superlist Name:
- Tramadol
- CAS No.:
27203-92-5
- Molecular Structure:
![Molecular Structure of 27203-92-5 (Cyclohexanol,2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)-, (1R,2R)-rel-)](http://www.lookchem.com/300w/2010/0620/27203-92-5.jpg)
- Formula:
- C16H25NO2
- Molecular Weight:
- 263.42
- Synonyms:
- Cyclohexanol,2-[(dimethylamino)methyl]-1-(m-methoxyphenyl)- (8CI);CG 315E;E 265;Racemic tramadol;Tiparol;Tramadis;Tramadol Contramid;Tramadon;Trapidol;U 26255A;Zytram;cis-Tramadol;
- EINECS:
- 248-319-6
- Density:
- 1.047 g/cm3
- Melting Point:
- 178-181 °C
- Boiling Point:
- 388.1 °C at 760 mmHg
- Flash Point:
- 188.5 °C
- Appearance:
- Light yellow oil
- Hazard Symbols:
Xn- Risk Codes:
- 22
- Transport Information:
- UN 2811 6.1/PG 3
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Chemistry
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IUPAC Name: (1R,2R)-2-(Dimethylaminomethyl)-1-(3-methoxyphenyl)cyclohexan-1-ol
Molecular Formula: C16H25NO2
Molecular Weight: 263.37
EINECS: 248-319-6
Index of Refraction: 1.532
Molar Refractivity: 77.96 cm3
Molar Volume: 251.3 cm3
Surface Tension: 39.6 dyne/cm
Density: 1.047 g/cm3
Flash Point: 188.5 °C
Enthalpy of Vaporization: 67.22 kJ/mol
Boiling Point: 388.1 °C at 760 mmHg
Vapour Pressure: 1.02E-06 mmHg at 25 °C
Melting point: 178-181 °C
Storage temp: 2-8°C
Appearance: white to off-white solid
Classification Code: Analgesics; Analgesics, opioid; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; Human Data; Narcotics; Peripheral Nervous System Agents; Sensory System Agents
Uses
Tramadol (CAS NO.27203-92-5) is an analgesic and used in the treatment of urinary incontinence. Tramadol is a centrally-acting analgesic, used for treating moderate to moderately severe pain. The drug has a wide range of applications, including treatment for restless leg syndrome, acid reflux, and fibromyalgia. It is used similarly to codeine, to treat moderate to moderately severe pain and most types of neuralgia, including trigeminal neuralgia.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| child | TDLo | intravenous | 4032ug/kg (4.032mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD KIDNEY, URETER, AND BLADDER: OTHER CHANGES | Southern Medical Journal. Vol. 90, Pg. 826, 1997. |
| rat | LD50 | intraperitoneal | 150mg/kg (150mg/kg) | European Patent Application. Vol. #0047990, | |
| rat | LD50 | oral | 228mg/kg (228mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| rat | LD50 | subcutaneous | 286mg/kg (286mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. | |
| women | TDLo | oral | 16mg/kg/4D-I (16mg/kg) | BEHAVIORAL: WAKEFULNESS BEHAVIORAL: EUPHORIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | American Journal of Psychiatry. Vol. 154, Pg. 1624, 1997. |
Safety Profile
Hazard Codes 
Xn
Risk Statements: 22
R22:Harmful if swallowed.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 2
Specification
Tramadol (CAS NO.27203-92-5), its Synonyms are Cyclohexanol, 2-((dimethylamino)methyl)-1-(m-methoxyphenyl)- ; Ralivia ER ; Ralivia flashtab ; Tradonal odis ; Ultram ; Cyclohexanol, 2-((dimethylamino)-1-(3-methoxyphenyl)-, cis-(+-)- ; Cyclohexanol, 2-((dimethylamino)methyl)-1-(3-methoxyphenyl)-, cis-(+-)- .