Basic information
- Name:
Tranexamic acid
- CAS No.:
1197-18-8
- Molecular Structure:
- Formula:
- C8H15NO2
- Molecular Weight:
- 157.21
- Synonyms:
- trans-4-Aminomethylcyclohexane-1-carboxylic acid;trans-4-(Aminomethyl)cyclohexanecarboxylic acid;trans-1-(Aminomethyl)cyclohexane-4-carboxylic acid;Acido tranexamico [INN-Spanish];4-(aminomethyl)cyclohexane-1-carboxylic acid;Cyclohexanecarboxylic acid, 4- (aminomethyl)-, trans-;Frenolyse;Tamcha;Cyclohexanecarboxylic acid,4-(aminomethyl)-,trans-;Trans-4-(Aminomethyl)cyclohexane-1-carboxylic acid;trans-1-Aminomethylcyclohexane-4-carboxylic acid;Tranex;trans-4-(Aminomethyl)cyclohexanecarboxylic acid; Tranexamic Acid;Tranesamic acid;CYCLO CAPRON;Transamin;Tranexan;Rikavarin-S;Rikavarin (TN);4-(Aminomethyl)cyclohexanecarboxylic acid;Hexatron;Trans-p-(Aminomethyl)cyclohexanecarboxylic acid;Amikapron;Cyclohexanecarboxylic acid, 4-(aminomethyl)-, trans-;Ugurol;trans-4-(Aminomethyl)-1-cyclohexanecarboxylic acid;
- EINECS:
- 214-818-2
- Density:
- 1.096 g/cm3
- Melting Point:
- 300 °C
- Boiling Point:
- 300.201 °C at 760 mmHg
- Flash Point:
- 135.357 °C
- Solubility:
- water: 1 g/6mL
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-36-37/39 Details
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Chemistry
Product Name: Tranexamic acid (CAS NO.1197-18-8)
Molecular Formula: C8H15NO2
Molecular Weight: 157.21g/mol
EINECS: 214-818-2
Melting point: 300 °C
Water solubility: 1g/6ml
Storage temp.: Store at 0 °C
Index of Refraction: 1.497
Molar Refractivity: 42.007 cm3
Molar Volume: 143.445 cm3
Surface Tension: 43.639 dyne/cm
Density: 1.096 g/cm3
Flash Point: 135.357 °C
Enthalpy of Vaporization: 59.426 kJ/mol
Boiling Point: 300.201 °C at 760 mmHg
XLogP3-AA: -2
H-Bond Donor: 2
H-Bond Acceptor: 2
Structure Descriptors of Tranexamic acid (CAS NO.1197-18-8):
IUPAC Name: 4-(aminomethyl)cyclohexane-1-carboxylic acid
Canonical SMILES: C1CC(CCC1CN)C(=O)O
InChI: InChI=1S/C8H15NO2/c9-5-6-1-3-7(4-2-6)8(10)11/h6-7H,1-5,9H2,(H,10,11)
InChIKey: GYDJEQRTZSCIOI-UHFFFAOYSA-N
Product Categories: 4-Substituted Cyclohexanecarboxylic Acids; API's
Toxicity Data With Reference
| 1. | orl-mus TDLo:9 mg/kg (female 7-12D post):REP | OYYAA2 Oyo Yakuri. Pharmacometrics. 5 (1971),415. | ||
| 2. | orl-rat TDLo:9 mg/kg (female 9-14D post):TER | OYYAA2 Oyo Yakuri. Pharmacometrics. 5 (1971),415. | ||
| 3. | orl-rat LD50:3000 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 22 (1965),340. | ||
| 4. | ipr-rat LD50:4200 mg/kg | MEIEDD Merck Index. 10 (1983),1269. | ||
| 5. | scu-rat LD50:4620 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 6. | ivn-rat LD50:1200 mg/kg | APTOA6 Acta Pharmacologica et Toxicologica. 22 (1965),340. | ||
| 7. | scu-mus LD50:5310 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 8. | ivn-mus LD50:1350 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. | ||
| 9. | ivn-dog LD50:1110 mg/kg | NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982” Edited by Japan Pharmaceutical Information Center. 6 (1982),512. |
Safety Profile
Moderately toxic by ingestion and intravenous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes such as NOx. A hemostatic agent.
The Hazard Codes of Tranexamic acid (CAS NO.1197-18-8) Xi:
;
The Risk Statements R36/37/38 : Irritating to eyes, respiratory system and skin.
The Safety Statements S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.S37/39 : Wear suitable gloves and eye/face protection.
Specification
Tranexamic acid , its CAS NO. is 1197-18-8, the synonyms are trans-4-Aminomethylcyclohexane-1-carboxylate ; trans-4-(Aminomethyl)cyclohexanecarboxylic acid ; Amstat .