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Cas Database |
| Name |
Trifluoroacetic anhydride |
EINECS | 206-982-9 |
| CAS No. | 407-25-0 | Density | 1.641 g/cm3 |
| PSA | 43.37000 | LogP | 1.18080 |
| Solubility | hydrolysis with water | Melting Point |
-63.5 °C |
| Formula | C4F6O3 | Boiling Point | 39.5 °C at 760 mmHg |
| Molecular Weight | 210.033 | Flash Point | -26 °C |
| Transport Information | UN 3265 8/PG 1 | Appearance | Clear, colorless liquid |
| Safety | 26-36/37/39-43-45-61-9-8-28A-27 | Risk Codes | 14-20-35-52/53-34-23/24/25 |
| Molecular Structure |
|
Hazard Symbols |
 C,  T
|
| Synonyms |
Aceticacid, trifluoro-, anhydride (6CI,8CI,9CI);2,2,2-Trifluoroacetic anhydride;Bis(trifluoroacetic) anhydride;Hexafluoroacetic anhydride;NSC 96965;Perfluoroacetic anhydride;Trifluoroacetic acid anhydride;Trifluoroacetyl anhydride;Trifluoroacetic anhydride(TFAA); |
Article Data | 75 |
Trifluoroacetic anhydride Synthetic route
- 64899-09-8
N-(n-butyl)-2,4-dinitrotrifluoroacetanilide
A
- 13059-86-4
2,4-dinitro-N-butylaniline
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| With tris buffers; cetyltrimethylammonim bromide at 25℃; Rate constant; hydrolysis, other quaterner amines; | A 99.7% B n/a |
| Conditions | Yield |
|---|---|
| With fuming sulphuric acid at 130℃; Large scale; | 99% |
| With fuming sulphuric acid at 78 - 130℃; Large scale; | 99% |
| With sulfuric acid; sulfur trioxide at 130℃; | 99% |
- 421-59-0
trifluoromethyldiiodophosphine
- 2966-50-9
silver trifluoroacetate
A
- 1682-76-4
Trifluormethylphosphonigsaeure-bis(trifluoressigsaeure)anhydrid
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| within 10 h; | A n/a B 98% |
| 10 min; isolation from volatile part of product; | A n/a B 72% |
- 1493-13-6
trifluorormethanesulfonic acid
- 76-05-1
trifluoroacetic acid
A
- 407-25-0
trifluoroacetic anhydride
B
- 68602-57-3
trifluoroacetyl triflate
| Conditions | Yield |
|---|---|
| With phosphorus pentoxide at -20 - 240℃; for 3.5h; | A n/a B 75% |
- 86024-51-3
Cl2SNTeF5
- 2966-50-9
silver trifluoroacetate
A
- 86024-52-4
F5TeNSO
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| In neat (no solvent) Cl2S=NTeF5 and CF3COOAg stirred at room temp. and warmed to 45°Cand stirred for 1 h; O=S=NTeF5 and (CF3CO)2O condensed into -196°C trap under vac., separation achieved by trap-to-trap distillation through -45 (O=S=NTeF5) and -78°C cooled traps; elem. anal.; | A 68% B n/a |
- 407-38-5
2,2,2-trifluoroethyl trifluoroacetate
A
- 353-50-4
Carbonyl fluoride
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| With chlorine at 22.84℃; under 760 Torr; Irradiation; Synthetic gas; | A 35% B 45% |
- 13257-51-7
mercury(II) trifluoroacetate
- 2757-23-5
chloro(chlorosulfanyl)methanone
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| at 50 - 55℃; for 3h; | 30% |
- 650-09-9
O,O-Diethyl O-Trifluoroacetyl Phosphate
A
- 107-49-3
Tetraethyl pyrophosphate
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| Erhitzen im Vakuum; |
- 350-70-9
tris(trifluoro acetyloxy)borane
A
- 330-25-6
tetrakis-trifluoroacetoxy-diboroxane
B
- 407-25-0
trifluoroacetic anhydride
| Conditions | Yield |
|---|---|
| at 100℃; under 0.0001 Torr; | |
| at 100℃; under 0.0001 Torr; |
| Conditions | Yield |
|---|---|
| With phosphorus at 180℃; | |
| With sulfur at 300℃; |
Trifluoroacetic anhydride Chemical Properties
Product Name: Trifluoroacetic anhydride
Molecular Formula: C4F6O3
Molecular Weight: 210.03g/mol
Mol File: 407-25-0.mol
Einecs: 206-982-9
Appearance: Clear, colorless liquid
Melting Point: -65 °C, 208 K, -85 °F
Boiling point: 40 °C, 313 K, 104 °F
Storage Temperature: 2-8°C
Density: 1.641 g/cm3
Index of Refraction: 1.291
Water Solubility: Hydrolysis
Sensitive: Moisture Sensitive
Surface Tension: 19.3 dyne/cm
Enthalpy of Vaporization: 28.41 kJ/mol
Vapour Pressure of Trifluoroacetic anhydride (CAS NO.407-25-0): 439 mmHg at 25 °C
Product Categories: Halogen compounds; Organics; Organic Fluorides; Acylation (GC Derivatizing Reagents); Analytical Chemistry; Fluorinated Building Blocks; Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds; GC Derivatizing Reagents; Synthetic Organic Chemistry
Trifluoroacetic anhydride Production
Trifluoroacetic anhydride (CAS NO.407-25-0) may be prepared from trifluoroacetic acid by dehydrating with excess α-halogenated acid chlorides. For example, with dichloroacetyl chloride:
2 CF3COOH + Cl2CHCOCl → (CF3CO)2O + Cl2CHCOOH + HCl
Trifluoroacetic anhydride Toxicity Data With Reference
Trifluoroacetic anhydride (CAS NO.407-25-0) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information.
Trifluoroacetic anhydride Safety Profile
Safety Information of Trifluoroacetic anhydride (CAS NO.407-25-0):
Hazard Codes: C.gif){kind=small}
,T.gif){kind=small}
Risk Statements: 14-20-35-52/53-34-23/24/25
14: Reacts violently with water
20: Harmful by inhalation
23: Toxic by inhalation
24: Toxic in contact with skin
25: Toxic if swallowed
34: Causes burns
35: Causes severe burns
52: Harmful to aquatic organisms
53: May cause long-term adverse effects in the aquatic environment
Safety Statements: 26-36/37/39-43-45-61-9-8-28A-27
8: Keep container dry
9: Keep container in a well-ventilated
place
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
27: Take off immediately all contaminated clothing
28: After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer)
36: Wear suitable protective clothing
37: Wear suitable gloves
39: Wear eye/face protection
43: In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add - Never use water)
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
Trifluoroacetic anhydride Specification
Trifluoroacetic anhydride , its CAS NO. is 407-25-0,the synonyms is Aceticacid,trifluoro-,anhydride ; Anhydrid kyseliny trifluoroctove ; Anhydridkyselinytrifluoroctove ; Hexafluoroacetic anhydride ; Hexafluoroaceticanhydride ; Perfluoroacetic anhydride ; Perfluoroaceticanhydride ; Trifluoroacetic . In addition, Trifluoroacetic anhydride (CAS NO.407-25-0) could be stable under normal temperatures and pressures, and it absorbs moisture or water from the air. It is not compatible with water, metals, strong oxidizing agents, strong acids, strong bases, alcohols, alkali metals. And also prevent it to broken down into hazardous decomposition products: carbon monoxide, carbon dioxide, hydrogen fluoride gas, fluorine. It will not occur hazardous polymerization.
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