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Trypsin

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Name

Trypsin

EINECS 232-650-8
CAS No. 9002-07-7 Density 1.37[at 20℃]
PSA 0.00000 LogP 0.00000
Solubility Soluble in water (10 mg/ml), phosphate buffers (10 mg/ml), and balanced salt solutions (1 mg/ml). Melting Point 115°C
Formula Unspecified Boiling Point N/A
Molecular Weight 372.1 Flash Point N/A
Transport Information N/A Appearance white or whitish powder
Safety 22-24-26-36/37-45-23 Risk Codes Xn,B
Molecular Structure Molecular Structure of 9002-07-7 (Trypsin) Hazard Symbols R36/37/38:; R42:;
Synonyms

Cocoonase;Pancreatic Trypsin Novo;Parenzyme;Parenzymol;Pseudotrypsin;Sperm receptor hydrolase;Tripcellim;Tryptar;Tryptec Formula One;Trypure;Trypzean;Typtar;

 

Trypsin Consensus Reports

Reported in EPA TSCA Inventory.

Trypsin Specification

The IUPAC name of this chemical is Trypsin. The CAS registry number is 9002-07-7 and the EINECS registry number is 232-650-8. It is converted into its active form by enteropeptidase in the small intestine. And it is a serine protease found in the digestive system of many vertebrates, where it hydrolyses proteins. It belongs to the class of Hydrolases; Specialty Enzymes; Diagnostic reagents; ProteasesAnalytical Enzymes; Trypsin for General Research ApplicationsCell Culture; USP Chemicals and Reagents Enzyme Class Index; Cell DissociationApplication Index; Reagents and Supplements; Enzymes, Inhibitors, and Substrates; ProteasesEnzyme Class Index.

Preparation of Trypsin: it is produced in the pancreas in the form of the inactive zymogen trypsinogen. When the pancreas is stimulated by cholecystokinin, it is then secreted into the first part of the small intestine the duodenum via the pancreatic duct.

Uses of Trypsin: it has been used widely in various biotechnological processes. It can be used to re-suspend cells adherent to the cell culture dish wall during the process of harvesting cells. It can also be used to dissociate dissected cells. In addition, it can be used to break down casein in breast milk. Moreover, it is used to dissolve blood clots in its microbial form and treat inflammation in its pancreatic form. Besides, it is used in baby food to pre-digest it.

When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. And it may cause sensitization by inhalation and skin contact. During using it, wear suitable protective clothing and gloves and do not breathe dust and vapour. You should avoid contact with skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intravenous 30000units/kg (30000units/kg) BEHAVIORAL: GENERAL ANESTHETIC

BLOOD: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Archives Internationales de Pharmacodynamie et de Therapie. Vol. 106, Pg. 164, 1956.
mouse LD50 intramuscular 105mg/kg (105mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   Farmakologiya i Toksikologiya Vol. 45(6), Pg. 78, 1982.
mouse LD50 intravenous 11100ug/kg (11.1mg/kg)   Drugs in Japan Vol. 6, Pg. 523, 1982.
mouse LD50 oral 1450mg/kg (1450mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.
rabbit LD50 intravenous 2200ug/kg (2.2mg/kg)   Drugs in Japan Vol. 6, Pg. 523, 1982.
rat LD50 intramuscular 200mg/kg (200mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.
rat LD50 intraperitoneal > 51mg/kg (51mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.
rat LD50 intravenous 36mg/kg (36mg/kg)   Farmakologiya i Toksikologiya Vol. 45(6), Pg. 78, 1982.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 744, 1990.

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