Uracil

  Uracil (CAS NO.66-22-8) is Originally discovered in 1900, and was isolated by hydrolysis of yeast nuclein which found in bovine thymus and spleen, herring sperm, and wheat germ.

EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory.

The Uracil, with the CAS registry number 66-22-8 and EINECS registry number 200-621-9, has the IUPAC name of 1H-pyrimidine-2,4-dione. It is a kind of white powder, and belongs to the following product categories: Heterocyclic Compounds; Pyrimidines; Biochemistry; Nucleobases and their analogs; Nucleosides, Nucleotides & Related Reagents; Nutritional Supplements; Nucleic acids. It is very stable, and incompatible with strong oxidizing agents. The molecular formula of the chemical is C₄H₄N₂O₂. What's more, while dealing with this chemical, you should not breathe dust and then try to avoid contacting with skin and eyes. 

The Uracil is a common and naturally occurring pyrimidine derivative, and can be found in RNA. It was isolated by hydrolysis of yeast nuclein that was found in bovine thymus and spleen, herring sperm, and wheat germ. And it can be used for drug delivery and as a pharmaceutical.

The physical properties of Uracil are as followings: (1)ACD/BCF (pH 5.5): 1; (2)ACD/BCF (pH 7.4): 1; (3)ACD/KOC (pH 5.5): 6.494; (4)ACD/KOC (pH 7.4): 5.915; (5)#H bond acceptors: 4; (6)#H bond donors: 2; (7)#Freely Rotating Bonds: 0; (8)Polar Surface Area: 58.2 Å²; (9)Index of Refraction: 1.502; (10)Molar Refractivity: 25.008 cm³; (11)Molar Volume: 84.809 cm³; (12)Polarizability: 9.914×10^-24cm³; (13)Surface Tension: 41.304 dyne/cm; (14)Density: 1.322 g/cm³.

Preparation: This chemical can be prepared by Malic acid, sulfuric acid and urea. The reaction equation is as follows:

You should be cautious while dealing with this chemical. It irritates to eyes, respiratory system and skin. Therefore, you had better take the following instructions: Do not breathe dust and avoid contacting with skin and eyes; Wear suitable protective clothing, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: c1c[nH]c(=O)[nH]c1=O
(2)InChI: InChI=1/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
(3)InChIKey: ISAKRJDGNUQOIC-UHFFFAOYAV

The toxicity data is as follows: