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Usnic acid

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Name

Usnic acid

EINECS 231-456-0
CAS No. 125-46-2 Density 1.49 g/cm3
PSA 117.97000 LogP 1.49980
Solubility N/A Melting Point 200 °C
Formula C18H16O7 Boiling Point 594.8 °C at 760 mmHg
Molecular Weight 344.321 Flash Point 219.1 °C
Transport Information N/A Appearance N/A
Safety 22-24/25 Risk Codes  Xn:Harmful;
Molecular Structure Molecular Structure of 125-46-2 (USNIC ACID) Hazard Symbols R22:;
Synonyms

Usnic acid(8CI);NSC 8517;Usnein;Usniacin;Usno;

 

Usnic acid Chemical Properties

IUPAC Name: 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione
The MF of 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione (125-46-2) is C18H16O7.

                                      
The MW of 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione (125-46-2) is 344.32.
Synonyms of 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione (125-46-2):
Usnic acid ; 1,3(2H,9bH)-Dibenzofurandione, 2,6-diacetyl-7,9-dihydroxy-8,9b-dimethyl- ; 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzo[b,d]furan-1,3(2H,9bH)-dione
Product Categories: Miscellaneous Natural Products
Form: Yellow orthorhombic prism-shaped crystal
Index of Refraction: 1.643 
EINECS: 231-456-0
Density: 1.49 g/ml 
Flash Point: 219.1 °C
Boiling Point: 594.8 °C
Melting Point: 200 °C
Merck: 9893

Usnic acid Uses

  2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione (125-46-2) is broad-spectrum antibiotics used for most Gram-positive bacteria with strong inhibition, but also inhibit the growth of Mycobacterium tuberculosis.

Usnic acid Toxicity Data With Reference

1.    

dnd-esc 20 µmol/L

    MUREAV    Mutation Research. 89 (1981),95.
2.    

cyt-mam:oth 3750 µg/L

    PHMCAA    Pharmacologist. 12 (1970),280.
3.    

ivn-mus LD50:25 mg/kg

    MEIEDD    Merck Index. 10 (1983),1414.
4.    

scu-mus LD50:75 mg/kg

    85GDA2    CRC Handbook of Antibiotic Compounds. 9 (1982),89.
5.    

ivn-mus LD50:25 mg/kg

    MEIEDD    Merck Index. 10 (1983),1414.
6.    

orl-rbt LD50:500 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 5 (1955),507.

Usnic acid Consensus Reports

Reported in EPA TSCA Inventory.

Usnic acid Safety Profile

Poison by subcutaneous and intravenous routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. Used as an antibacterial and antimitotic agent.
Safety information of 2,6-Diacetyl-7,9-dihydroxy-8,9b-dimethyldibenzofuran-1,3-dione (125-46-2):
Safety Statements 
22  Do not breathe dust
24/25  Avoid contact with skin and eyes
RTECS  HP5270000

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