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Name	VINDESINE	EINECS	258-682-2
CAS No.	53643-48-4	Density	1.41g/cm³
PSA	164.82000	LogP	3.37350
Solubility	N/A	Melting Point	230-232oC
Formula	C43H55 N5 O7	Boiling Point	°Cat760mmHg
Molecular Weight	753.939	Flash Point	°C
Transport Information	N/A	Appearance	N/A
Safety	Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	1H-Indolizino[8,1-cd]carbazole,vincaleukoblastine deriv.; 2H-3,7-Methanoazacycloundecino[5,4-b]indole,vincaleukoblastine deriv.; Compound 112531; Vindesine

VINDESINE Chemical Properties

IUPAC Name: 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine
The MF of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is C₄₃H₅₅N₅O₇.

The MW of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is 753.93.
Synonyms of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4): Compound 112531 ; Eldisine ; Fildesin ; VDS ; Vindesine
Apperance: ethanol - methanol crystallization
Melting Point: 230～232 °C
Index of Refraction: 1.708
EINECS: 258-682-2
Density: 1.41 g/ml

VINDESINE Uses

3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4) is used as anti-cancer drug.Its mechanism inhibit the proliferation of cells, spindle formation, so that cell growth stopped in mid-mitosis for cell cycle-specific drugs. For lung cancer, malignant lymphoma, breast cancer, esophageal cancer, childhood acute lymphoblastic leukemia, chronic myelogenous leukemia, melanoma, germ cell tumors, ovarian cancer and so on.

VINDESINE Production

With vinblastine as raw materials, under normal pressure, and the reaction of anhydrous hydrazine and then restore the received vindesine.

VINDESINE Toxicity Data With Reference

1.	mnt-ipr-ham 1100 µg/kg	MUREAV Mutation Research. 174 (1986),11.
2.	ipr-mus LD50:4 mg/kg	BAXXDU British UK Patent Application. (U.S. Patent Office, Science Library, 2021 Jefferson Davis Highway, Arlington, VA 22202) #2086884 .
3.	ivn-mus LD50:13800 µg/kg	JMCMAR Journal of Medicinal Chemistry. 28 (1985),1079.

VINDESINE Safety Profile

Mutation data reported. When heated to decomposition it emits toxic vapors of NO_x.
Safety information of 3-(Aminocarbonyl)-O4-deacetyl-3-de(methoxycarbonyl)vincaleukoblastine (53643-48-4):
RIDADR 1544
HazardClass 6.1(a)
PackingGroup II

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