Valsartan (137862-53-4),Valsartan (137862-53-4) Manufacturers & Suppliers,Synthesis,MSDS

Basic information

Name:
Valsartan
CAS No.:
137862-53-4
Molecular Structure:
Formula:
C₂₄H₂₉N₅O₃
Molecular Weight:
435.52 .
Synonyms:
L-Valine,N-(1-oxopentyl)-N-[[2'-(1H-tetrazol- 5-yl)[1,1'-biphenyl]-4-yl]methyl]-;Diovan;Diovan (TN);L-Valine, N-(1-oxopentyl)-N-((2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)methyl)-;N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine;Valsartan [USAN:INN];N-(1-n.Pentanoyl)-N-[[2'-(1H-tetrazol-5-yl)[1',1- biphenyl]-4-yl]methyl]-L-valine;Dihydrotachystero;Valsartan USP30;
Density:
1.212 g/cm³
Melting Point:
116-117 °C
Boiling Point:
684.9 °C at 760 mmHg
Flash Point:
368 °C
Appearance:
white crystalline powder
Hazard Symbols:
Xi
Risk Codes:
36/37/38
Safety Description:
26-37/39 Details

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Chemistry

Structure of Valsartan (CAS NO.137862-53-4):

IUPAC Name: (2S)-3-Methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoic acid
Molecular Formula: C₂₄H₂₉N₅O₃
Molar mass: 435.5188 g/mol
Density: 1.212 g/cm³
Flash Point: 368 °C
Index of Refraction: 1.586
Boiling Point: 684.9 °C at 760 mmHg
Vapour Pressure: 1.06E-19 mmHg at 25 °C
Melting Point: 116-117 °C
Appearance: white crystalline powder
XLogP3-AA: 4.4
H-Bond Donor: 2
H-Bond Acceptor: 6
Rotatable Bond Count: 10
Tautomer Count: 2
Exact Mass: 435.22704
MonoIsotopic Mass: 435.22704
Topological Polar Surface Area: 112
Heavy Atom Count: 32
Canonical SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)C(C(C)C)C(=O)O
Isomeric SMILES: CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[C@@H](C(C)C)C(=O)O
InChI: InChI=1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
InChIKey: ACWBQPMHZXGDFX-QFIPXVFZSA-N
Product Categories: Active Pharmaceutical Ingredients; Antihypertensive; APIs; Intermediates & Fine Chemicals; Pharmaceuticals; API's

Uses

Valsartan (CAS NO.137862-53-4) is indicated for treatment of high blood pressure, congestive heart failure (CHF), or post-myocardial infarction (MI) in the U.S.. A study released by the Journal of Clinical Investigation in 2007 found some efficacy in the use of valsartan in the treatment and prevention of Alzheimer's Disease although such use is considered to be highly experimental.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.

Specification

Valsartan (CAS NO.137862-53-4) is also named as CGP 48933 ; Diovan ; HSDB 7519 ; UNII-80M03YXJ7I ; Valtan ; Valzaar ; L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- ; N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine . It is an angiotensin II receptor antagonist (more commonly called an "ARB", which stands for angiotensin receptor blocker), with particularly high affinity for the type I (AT₁) angiotensin receptor.