Basic information
- Name:
Venlafaxine hydrochloride
- CAS No.:
99300-78-4
- Molecular Structure:
- Formula:
- C17H28ClNO2
- Molecular Weight:
- 313.86
- Synonyms:
- 1-[2-dimethylamino-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol;Cyclohexanol,1-[2-(dimethylamino)-1-(4- methoxyphenyl)ethyl]-,hydrochloride;Venlafaxina [INN-Spanish];venlafaxine HCl;Effexor XR;Elafax;Venlafaxine hydrochloride (JAN/USAN);Effexor (TN);Cyclohexanol, 1-(2-(dimethylamino)-1-(4-methoxyphenyl)ethyl)-, hydrochloride;Venlafaxine Hydrochlorid;Venlafaxin HCL;Wy-45030;Effexor;Wy-45,030;Venlafaxinum [INN-Latin];(+-)-1-(alpha-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride;N,N-dimethyl-2-p-methoxy- phenyl-2-(1-hydroxycyclohexyl) ethylamine hyd- rochloride;
- Melting Point:
- 207-209 °C
- Boiling Point:
- 397.6 °C at 760 mmHg
- Flash Point:
- 194.2 °C
- Appearance:
- white crystalline powder
- Hazard Symbols:
Xi- Risk Codes:
- 36/37/38
- Safety Description:
- 26-37/39 Details
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Chemistry
Molecular structure of Venlafaxine hydrochloride (CAS NO.99300-78-4) is:
Product Name: Venlafaxine hydrochloride
CAS Registry Number: 99300-78-4
IUPAC Name: 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-olhydrochloride
Molecular Weight: 313.86272 [g/mol]
Molecular Formula: C17H28ClNO2
H-Bond Donor: 2
H-Bond Acceptor: 3
Melting Point: 207-209 °C
Flash Point: 194.2 °C
Enthalpy of Vaporization: 68.34 kJ/mol
Boiling Point: 397.6 °C at 760 mmHg
Vapour Pressure: 4.92E-07 mmHg at 25°C
Product Categories: Active Pharmaceutical Ingredients;Medicine intermediate;Antidepressant;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor
Uses
Venlafaxine hydrochloride (CAS NO.99300-78-4) can be used as a selective serotonin noradrenaline reuptake inhibitor and also used as an antidepressant. And, it is used primarily for the treatment of major depression in adults.
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 1071ug/kg (1.071mg/kg) | SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 211, 1997. |
| man | TDLo | oral | 32mg/kg/9W-I (32mg/kg) | BEHAVIORAL: HEADACHE BEHAVIORAL: WITHDRAWAL | Medical Journal of Australia. Vol. 169, Pg. 91, 1998. |
| women | LDLo | oral | 168mg/kg (168mg/kg) | BEHAVIORAL: COMA CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Medical Journal of Australia. Vol. 169, Pg. 445, 1998. |
| women | LDLo | oral | 235mg/kg/12D- (235mg/kg) | LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" GASTROINTESTINAL: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA | Journal of Analytical Toxicology. Vol. 20, Pg. 266, 1996. |
| women | TDLo | oral | 94500ug/kg/9W (94.5mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" SKIN AND APPENDAGES (SKIN): SWEATING: OTHER | Annals of Pharmacotherpy. Vol. 33, Pg. 1009, 1999. |
| women | TDLo | oral | 315mg/kg/30W- (315mg/kg) | BEHAVIORAL: WITHDRAWAL GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING | Medical Journal of Australia. Vol. 169, Pg. 91, 1998. |
| women | TDLo | oral | 360mg/kg/17W- (360mg/kg) | BEHAVIORAL: WITHDRAWAL SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Medical Journal of Australia. Vol. 169, Pg. 91, 1998. |
Safety Profile
Hazard Codes: 
Xi
Risk Statements 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
Specification
Venlafaxine hydrochloride , its cas register number is 99300-78-4. It also can be called (+/-)-1-(alpha-((Dimethylamino)methyl)-p-methoxybenzyl)cyclohexanol hydrochloride ; (RS)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride ; Effexor .It is a white crystalline powder.