Basic information
- Name:
Voriconazole
- CAS No.:
137234-62-9
- Molecular Structure:

- Formula:
- C16H14F3N5O
- Synonyms:
- 4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-,(alphaR,betaS)-;DRG-0301;UK-109,496;UNII-JFU09I87TR;Vfend;VRC;
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- 22255-10-3[(3S,6aR,6bS,8aR,11R,12S,12aS,14aS,14bS)-4,4,6a,6b,8a,11,12,14b-octamethyl-2,3,4a,5,6,7,8,9,10,11,12,12a,14,14a-tetradecahydro-1H-picen-3-yl] hexadecanoate
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Chemistry
Molecular structure of Voriconazole (CAS NO.137234-62-9) is:

Product Name: Voriconazole
CAS Registry Number: 137234-62-9
IUPAC Name: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
Molecular Weight: 349.31047 [g/mol]
Molecular Formula: C16H14F3N5O
XLogP3-AA: 1.5
H-Bond Donor: 1
H-Bond Acceptor: 8
Melting Point: 127-130 °C
Surface Tension: 45.1 dyne/cm
Density: 1.42 g/cm3
Flash Point: 261.4 °C
Enthalpy of Vaporization: 82.02 kJ/mol
Boiling Point: 508.6 °C at 760 mmHg
Vapour Pressure: 3.63E-11 mmHg at 25°C
Product Categories: API; Antifungal (Systemic); Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals
History
London, UK, 16 December 2008 - The effectiveness of voriconazole in combating fungal infections has been confirmed by a new study to be featured in the International Journal of Antimicrobial Agents ,published by Elsevier.
Uses
Voriconazole (CAS NO.137234-62-9) is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.
Toxicity Data With Reference
The most common side effects associated with voriconazole(137234-62-9) include transient visual disturbances, fever, rash, vomiting, nausea, diarrhea, headache, sepsis, peripheral edema, abdominal pain, and respiratory disorder.This medication may also cause the skin to peel easily. It is best to apply lotion and/or coconut oil to help with this side effect.
Safety Profile
Safty information about Voriconazole (CAS NO.137234-62-9) is:
Hazard Codes:
Xn
Risk Statements: 22-36/38
R22:Harmful if swallowed.
R36/38:Irritating to eyes and skin.
Safety Statements: 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Specification
Voriconazole , its cas register number is 137234-62-9. It also can be called Voriconazole [USAN:INN:BAN] ; (alphaR,betaS)-alpha-(2,4-Difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol ; 4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-,(alphaR,betaS)- ; DRG-0301 ; UK-109,496 ; UNII-JFU09I87TR ; VRC ; Vfend ; Voriconazole ; (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol ; 4-Pyrimidineethanol, alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-, (R-(R*,S*))- . It is a cyrstalline solid.
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