Basic information
- Name:
Latanoprost
- CAS No.:
130209-82-4
- Molecular Structure:
- Formula:
- C26H40O5
- Molecular Weight:
- 432.66
- Synonyms:
- Lata prostaglandin;Latanoprost [USAN:BAN:INN];XA 41;Xalatan (TN);5-Heptenoic acid, 7-(3,5-dihydroxy-2-(3-hydroxy-5-phenylpentyl)cyclopentyl)-, 1-methylethyl ester, (1R-(1-alpha(Z),2-beta(R*),3-alpha,5-alpha))-;Xalatan;PhXA 41;Isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate;Latanoprost (JAN/USAN);
- Density:
- 1.093 g/cm3
- Boiling Point:
- 583.8 °C at 760 mmHg
- Flash Point:
- 188.3 °C
- Solubility:
- Soluble in: DMSO (25 mg/mL); ethanol (25 mg/mL)
- Appearance:
- pale yellow oil
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Chemistry
Formula: C26H40O5
Mol. mass :432.593 g/mol
Other name:Latanoprost
XALATAN the brand name of Xalatan manufactured by Pfizer.It is freely soluble in DMSO.
Following is the molecular structure of XALATAN:
Uses
XALATAN ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension by reducing intraocular pressure.
XALATAN is also a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.
XALATAN is also a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.
Toxicity Data With Reference
| 1. | ocu-man TDLo:33 µL/kg/25D-I:EYE | AJOPAA American Journal of Ophthalmology. 124 (1997),683. | ||
| 2. | ocu-man TDLo:99 µL/kg/20W-I:SKN | AJOPAA American Journal of Ophthalmology. 124 (1997),544. | ||
| 3. | ocu-wmn TDLo:4 nL/kg/5W-I:EYE | AJOPAA American Journal of Ophthalmology. 127 (1999),91. | ||
| 4. | orl-rat LD50:>50 µg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195. | ||
| 5. | ivn-rat LD50:>2 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195. | ||
| 6. | orl-mus LD50:>50 µg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195. | ||
| 7. | ivn-mus LD50:>2 mg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195. | ||
| 8. | ivn-dog LD50:>680 µg/kg | YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. 42 (2000),195. |
RTECS : MJ9669550
Safety Profile
A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.