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Basic information

  • Name:
  • D-Streptamine,O-2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl-(1®4)-O-[b-D-ribofuranosyl-(1®5)]-2-deoxy-

  • CAS No.:
  • 25546-65-0

  • Molecular Structure:
  • Formula:
  • C17H34 N4 O10
  • Molecular Weight:
  • 454.55
  • Synonyms:
  • AntibioticSF 733; Dekamycin IV; Hetangmycin; NSC 138925; Ribostamycin; SF 733; Vistamycin
  • Safety Description:
  • Poison by intravenous route. Moderately toxic by intramuscular and intraperitoneal routes. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx. Details

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Chemistry

IUPAC Name: 5-Amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
The MF of Ribostamycin sulfate salt (CAS NO.25546-65-0) is C17H36N4O14S.

                              
The MW of Ribostamycin sulfate salt (CAS NO.25546-65-0) is 552.55.
Synonyms of Ribostamycin sulfate salt (CAS NO.25546-65-0): Ribostamycin disulfate ; Ribostamycin sulfate salt ; Ribostamycin sulphate ; Antibioticsf733 ; Dekamyciniv ; D-Ribofuranosyl-(1-5))-2-deoxy- ; Hetangmycin
Flash Point: 502.7 °C
Boiling Point: 907.6 °C
Storage temp: 2-8 °C
EINECS: 247-091-5

Toxicity Data With Reference

1.    

ipr-rat LD50:4400 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),2464.
2.    

ivn-rat LD50:535 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),2464.
3.    

ims-rat LD50:1850 mg/kg

    NKRZAZ    Chemotherapy (Tokyo). 32 (1984),949.
4.    

orl-mus LD50:7000 mg/kg

    85GDA2    CRC Handbook of Antibiotic Compounds. 1 (1980),141.
5.    

ipr-mus LD50:2830 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),2464.
6.    

scu-mus LD50:3350 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),2464.
7.    

ivn-mus LD50:300 mg/kg

    KSRNAM    Kiso to Rinsho. Clinical Report. 4 (1970),2464.
8.    

ims-mus LD50:1600 mg/kg

    85GDA2    CRC Handbook of Antibiotic Compounds. 1 (1980),141.

Consensus Reports

EPA Genetic Toxicology Program.

Safety Profile

Poison by intravenous route. Moderately toxic by intramuscular and intraperitoneal routes. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.Safety information of Ribostamycin sulfate salt (CAS NO.25546-65-0):
Hazard Codes  ToxicT
Risk Statements 
61 May cause harm to the unborn child
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
Safety Statements 
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany  3
RTECS  WK2300000

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