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tetra-N-acetylribostamycin
ribostamycin
Conditions | Yield |
---|---|
With hydrazine hydrate at 100℃; for 66h; sealed tube; | 59% |
1,3,2',6'-Tetra-N-(benzyloxycarbonyl)-2'',3'',5''-tri-O-benzoyl-6,3',4'-tri-O-benzylribostamycin
ribostamycin
Conditions | Yield |
---|---|
With palladium on activated charcoal; hydrogen; sodium methylate; acetic acid 1.) MeOH, 3.5 h, 2.) aq. dioxane, 48 h, then water; Yield given. Multistep reaction; |
[(1S,2R,3R,5R)-2-[(2R,3R,4R,5S,6R)-3-Acetylamino-6-(acetylamino-methyl)-4,5-dihydroxy-tetrahydro-pyran-2-yloxy]-3-((2S,3R,4S,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yloxy)-4,6-dihydroxy-5-nitro-cyclohexyl]-carbamic acid benzyl ester
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min 3: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
C41H53N3O23
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: benzene; pyridine / 1 h / Heating 2: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature 3: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min 5: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
C55H66N4O18
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 2: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
C59H69N3O22
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: pyridine 2: 1.) BF3-Et2O; 2.) Jones reagent / 1.) THF, 2 deg C, 40 min; 2.) r.t., 4 h 3: benzene; pyridine / 1 h / Heating 4: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature 5: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min 7: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
C61H71N3O23
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 1.) BF3-Et2O; 2.) Jones reagent / 1.) THF, 2 deg C, 40 min; 2.) r.t., 4 h 2: benzene; pyridine / 1 h / Heating 3: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature 4: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min 6: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
C43H57N3O23
ribostamycin
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: 62 percent / NaOMe / methanol; nitromethane / 14 h / Ambient temperature 2: 1.) p-TsOH*H2O; 2.) pyridine; 3.) d-10-camphorsulfonic acid / 1.) DMF, 45 deg C, 50 min; 2.) r.t., 8 h; 3.) DMF, r.t., 10 min 4: 59 percent / 80percent aq. NH2NH2*H2O / 66 h / 100 °C / sealed tube View Scheme |
ribostamycin
γ-L-Glu-((S)-4-amino-2-hydroxybutyryl)-N-acetylcysteamine thioester
γ-L-Glu-butirosin B
Conditions | Yield |
---|---|
With recombinant BtrH enzyme at 20℃; for 6h; pH=7.9; aq. buffer; Enzymatic reaction; | 100% |
Conditions | Yield |
---|---|
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 50℃; for 72h; | 70% |
IUPAC Name: 5-Amino-2-(aminomethyl)-6-[4,6-diamino-2-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
The MF of Ribostamycin sulfate salt (CAS NO.25546-65-0) is C17H36N4O14S.
The MW of Ribostamycin sulfate salt (CAS NO.25546-65-0) is 552.55.
Synonyms of Ribostamycin sulfate salt (CAS NO.25546-65-0): Ribostamycin disulfate ; Ribostamycin sulfate salt ; Ribostamycin sulphate ; Antibioticsf733 ; Dekamyciniv ; D-Ribofuranosyl-(1-5))-2-deoxy- ; Hetangmycin
Flash Point: 502.7 °C
Boiling Point: 907.6 °C
Storage temp: 2-8 °C
EINECS: 247-091-5
1. | ipr-rat LD50:4400 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),2464. | ||
2. | ivn-rat LD50:535 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),2464. | ||
3. | ims-rat LD50:1850 mg/kg | NKRZAZ Chemotherapy (Tokyo). 32 (1984),949. | ||
4. | orl-mus LD50:7000 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 1 (1980),141. | ||
5. | ipr-mus LD50:2830 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),2464. | ||
6. | scu-mus LD50:3350 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),2464. | ||
7. | ivn-mus LD50:300 mg/kg | KSRNAM Kiso to Rinsho. Clinical Report. 4 (1970),2464. | ||
8. | ims-mus LD50:1600 mg/kg | 85GDA2 CRC Handbook of Antibiotic Compounds. 1 (1980),141. |
EPA Genetic Toxicology Program.
Poison by intravenous route. Moderately toxic by intramuscular and intraperitoneal routes. Mildly toxic by ingestion. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.Safety information of Ribostamycin sulfate salt (CAS NO.25546-65-0):
Hazard Codes T
Risk Statements
61 May cause harm to the unborn child
20/21/22 Harmful by inhalation, in contact with skin and if swallowed
Safety Statements
53 Avoid exposure - obtain special instruction before use
22 Do not breathe dust
36/37/39 Wear suitable protective clothing, gloves and eye/face protection
45 In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
WGK Germany 3
RTECS WK2300000