Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

Zoledronic acid
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

Zoledronic acid

 EINECS 1806241-263-5
CAS No. 118072-93-8 Density 2.13 g/cm3
PSA 172.73000 LogP -1.11540
Solubility N/A Melting Point 193-2040 ºC
Formula C5H10N2O7P2 Boiling Point 764 ºC at 760 mmHg
Molecular Weight 316.055 Flash Point 415.8 ºC
Transport Information N/A Appearance white crystalline powder
Safety 24/25-36/37/39 Risk Codes 21/22-36/37/38
Molecular Structure Molecular Structure of 118072-93-8 (Zoledronic acid) Hazard Symbols IrritantXi
Synonyms

Zometa (Novartis);Zometa;Zoledronate;(1-hydroxy-2-imidazol-1-yl-1-phosphono-ethyl)phosphonic acid;Phosphonic acid,[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-;(1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid;Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-;[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis Phosphonic acid;ZoledronicAcid;[1-hydroxy-(1H-imidazol-1-yl)-phosphonoethyl] phosphonic acid monohydrate;1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid;

Article Data 43

Zoledronic acid Synthetic route

22884-10-2

imidazol-1-ylacetic acid

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-ylacetic acid With phosphoric acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 40 - 60℃;
Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 (polyethylene glycol) at 85℃; for 18h; Product distribution / selectivity;		99%
Stage #1: imidazol-1-ylacetic acid With phosphorous acid; phosphorus trichloride In 1,2-propylene cyclic carbonate; PEG 600 at 40 - 60℃;
Stage #2: With water In 1,2-propylene cyclic carbonate; PEG 600 at 85℃; for 18h; Product distribution / selectivity;		99%
With sulfolane; phosphonic Acid; 1-butyl-3-methylimidazolium Tetrafluoroborate; phosphorus trichloride at 75℃; for 3h; Reagent/catalyst; Green chemistry;93%

C8H8N4O2*ClH

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: C8H8N4O2*ClH With phosphoric acid; phosphorus trichloride In toluene at 90℃;
Stage #2: With hydrogenchloride In water; toluene at 20℃; Reagent/catalyst; Temperature; Solvent; Reflux;		85.27%

2-(1-imidazolyl)acetic acid hydrochloride

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In silicon oil at 80℃; for 11 - 24h;
Stage #2: With water In toluene; silicon oil at 80 - 100℃; for 16 - 19h; Product distribution / selectivity;		74%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphorous acid; trichlorophosphate In toluene at 100℃; for 3h;
Stage #2: With water In toluene at 80 - 100℃; for 16h; Product distribution / selectivity;		69%
Stage #1: 2-(1-imidazolyl)acetic acid hydrochloride With phosphonic Acid; trichlorophosphate In chlorobenzene at 85 - 95℃; for 4.5h;
Stage #2: With water for 18h; Reflux;		64%
288-32-4

1H-imidazole

105-39-5

chloroacetic acid ethyl ester

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: 1H-imidazole; chloroacetic acid ethyl ester With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide In 1,4-dioxane at 20℃; for 0.5h; Reflux;
Stage #2: With phosphoric acid; phosphorus trichloride In 1,4-dioxane at 20℃; for 1h;
Stage #3: With hydrogenchloride In water for 6h; Reagent/catalyst;		60.5%
160975-66-6

imidazol-1-yl-acetyl chloride

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-yl-acetyl chloride With methanesulfonic acid; phosphorus trichloride at 26 - 80℃; for 16h;
Stage #2: With water at 26 - 110℃; for 5h;
Stage #3: With sodium hydroxide In water for 12h; pH=1.8;
1392687-52-3

tetrakis(O-trimethylsilyl)hydroxyethylidenediphosphonic acid

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
With water In ethanol for 0.5h;
827573-10-4

1-hydroxy-2-(1-imidazolyl)ethylidenebisphosphonic acid monosodium

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 89.84℃; for 0.25h; pH=1.5;
22884-10-2

imidazol-1-ylacetic acid

7719-12-2, 52843-90-0

phosphorus trichloride

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Stage #1: imidazol-1-ylacetic acid; phosphorus trichloride With methanesulfonic acid at 80℃; Green chemistry;
Stage #2: In water Green chemistry;
Stage #3: With sodium hydroxide In water Green chemistry;
17450-34-9

ethyl 2-(1H-imidazol-1-yl)acetate

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / water / 7 h / 100 °C / pH 1.5
2.1: phosphoric acid / water / 0.5 h / 100 °C
2.2: 3 h / 65 - 100 °C
2.3: 5 h / Reflux
View Scheme
Multi-step reaction with 2 steps
1: water
2: water; phosphoric acid; phosphorus trichloride / chlorobenzene
View Scheme

C11H14N4O2

118072-93-8

1-hydroxy-2-(imidazol-1-yl)ethylidene-1,1-bisphosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: hydrogenchloride / Reflux
2.1: phosphoric acid; phosphorus trichloride / toluene / 90 °C
2.2: 20 °C / Reflux
View Scheme

Zoledronic acid Chemical Properties


IUPAC Name: (1-Hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
Molecular Formula: C5H10N2O7P2
Molecular Weight: 272.09 g/mol
Canonical SMILES: c1cncn1CC(O)(P(O)(=O)O)P(O)(=O)O
InChI: InChI=1/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
Classification Code: Bone Density Conservation Agents
Product Categories: Pharmaceutical material and intermeidates; Bone resorption inhibitor; Antiosteoporotic; Zoledronate;All Inhibitors; Inhibitors; Intermediates & Fine Chemicals; Pharmaceuticals; Zoledronic
Density: 2.13 g/cm3
Flash Point: 415.8 °C
Enthalpy of Vaporization: 116.73 kJ/mol
Boiling Point: 764 °C at 760 mmHg
Melting Point: 193-2040 °C
Vapour Pressure of Zoledronic acid (CAS NO.118072-93-8): 1.53E-24 mmHg at 25 °C

Zoledronic acid History

 Zoledronic Acid is a single 5 mg infusion for the treatment of Paget's disease of bone. In 2007, the U.S. Food and Drug Administration (FDA) also approved Zoledronic Acid for the treatment of postmenopausal osteoporosis.

Zoledronic acid Uses

 Zoledronic acid (CAS NO.118072-93-8) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis. It can also be used to treat hypercalcemia of malignancy and can be helpful for treating pain from bone metastases.

Zoledronic acid Safety Profile

Hazard Codes: IrritantXi
Risk Statements: 21/22-36/37/38 
R21/22: Harmful in contact with skin and if swallowed. 
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements of Zoledronic acid (CAS NO.118072-93-8): 24/25-36/37/39 
S24/25: Avoid contact with skin and eyes. 
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

Zoledronic acid Specification

 Zoledronic acid (CAS NO.118072-93-8), its Synonyms are (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid ; Phosphonic acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis- ; Zoledronate ; Zometa ; Reclast ; Aclasta . It is white solid.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 118072-93-8