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Basic information

  • Name:
  • 1H-Indole-3-aceticacid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, carboxymethyl ester

  • Superlist Name:
  • Acemetacin
  • CAS No.:
  • 53164-05-9

  • Formula:
  • C21H18ClNO6
  • Synonyms:
  • 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-aceticacid carboxymethyl ester;1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-aceticacid carboxymethyl ester;2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]aceticacid;Acemet;Acemethacin;Acemix;Emflex;K 708;Rantudil;Rheumibis;Rheutrop;Solart;TV 1322;TVX 1322;
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Chemistry

Systematic (IUPAC) name :2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Formula: C21H18ClNO6 
Mol. mass :415.82372 g/mol

History

Acemetacin  is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug.

Uses

    Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain.
    Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects.

Consensus Reports

    An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.

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