acemetacin
(53164-05-9)
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Chemistry
Systematic (IUPAC) name :2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Formula: C21H18ClNO6
Mol. mass :415.82372 g/mol
History
Acemetacin is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug.
Uses
Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain.
Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects.
Consensus Reports
An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.
