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acemetacin (53164-05-9)

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Chemistry
Systematic (IUPAC) name :2-[2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetyl]oxyacetic acid
Formula: C21H18ClNO6 
Mol. mass :415.82372 g/mol
History
Acemetacin  is manufactured by Merck under the tradename Emflex, and is available in the UK as a prescription-only drug.
Uses

    Acemetacin is a non-steroidal anti-inflammatory drug, used for the treatment of osteoarthritis, rheumatoid arthritis, lower back pain, and relieving post-operative pain.
    Acemetacin, a glycolic acid ester of indometacin, acts as a prodrug; in the body, it is metabolized to indometacin, which then acts as an inhibitor of cyclooxygenase, producing the anti-inflammatory effects.

Consensus Reports
    An advantage of acemetacin is that it reduces gastric damage when compared to indometacin.

Basic information

  • Product Name:

    acemetacin

  • CAS No:53164-05-9
  • Formula:C21H18 Cl N O6
  • Synonyms:1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-aceticacid carboxymethyl ester; 1-(p-Chlorobenzoyl)-5-methoxy-2-methylindole-3-aceticacid carboxymethyl ester;2-[2-[1-[(4-Chlorophenyl)carbonyl]-5-methoxy-2-methylindol-3-yl]acetyloxy]aceticacid; Acemet; Acemetacin; Acemethacin; Acemix; Emflex; K 708; Rantudil;Rheumibis; Rheutrop; Solart; TV 1322; TVX 1322
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