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alpha-Lobeline hydrochloride

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Basic Information post buying leads Suppliers
Name alpha-Lobeline hydrochloride EINECS 205-150-2
CAS No. 134-63-4 Density
Solubility Melting Point 183-185 °C (dec.)(lit.)
Formula C22H28ClNO2 Boiling Point 485.6 °C at 760 mmHg
Molecular Weight 373.96 Flash Point 247.5 °C
Transport Information UN 1544 6.1/PG 3 Appearance White to off-white solid
Safety 36/37/39-45 Risk Codes 23/25
Molecular Structure Molecular Structure of 134-63-4 (alpha-Lobeline hydrochloride) Hazard Symbols ToxicT
Synonyms

Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-,hydrochloride (9CI);Ethanone,2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-,hydrochloride, [2R-[2a,6a(S*)]]-;Lobeline, hydrochloride(8CI);(-)-Lobeline hydrochloride;(-)-a-Lobeline hydrochloride;Lobelin hydrochloride;Lobron;Zoolobelin;

 

Chemistry

Chemical Name: alpha-Lobeline hydrochloride          
IUPAC NAME: 2-[(2R,6S)-6-[(2R)-2-Hydroxy-2-phenylethyl]-1-methylpiperidin-2-yl]-1-phenylethanone hydrochloride    
CAS No.: 134-63-4
EINECS: 205-150-2
RTECS: OJ8490100
Molecular Formula: C22H28ClNO2
Molecular Weight: 373.92 g/mol
Melting Point: 183-185 °C (dec.)(lit.)
Flash Point: 247.5 °C
Boiling Point: 485.6 °C at 760 mmHg
Following is the structure of Lobeline hydrochloride (134-63-4):


Product Categories are Alkaloids ; Heterocyclic Compounds ; Biochemistry ; Pyridine Alkaloids ; Neurochemicals ; Acetylcholine receptor                       
The chemical synonyms of Lobeline hydrochloride (CAS NO.134-63-4) are 2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)-acetophenonhydrochlor ; 2-[6-(.beta.-Hydroxyphenethyl)-1-methyl-2-piperidyl]-,hydrochloride,(-)-acetophenone ; lobelinhydrochloride ;  ; lobeline Hcl, a- ; (-)-lobeline hydrochloride              

Uses

  Lobeline hydrochloride (CAS NO.134-63-4) is used as a neuronal nicotinic acetylcholine receptor agonist and also used as a respiratory stimulant.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo parenteral 150mg/kg (150mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 163, Pg. 279, 1931.
mouse LD50 intraperitoneal 39900ug/kg (39.9mg/kg)   Drugs in Japan Vol. 6, Pg. 913, 1982.
mouse LD50 intravenous 7800ug/kg (7.8mg/kg)   Drugs in Japan Vol. 6, Pg. 913, 1982.
mouse LD50 subcutaneous 87500ug/kg (87.5mg/kg)   Drugs in Japan Vol. 6, Pg. 913, 1982.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and HCl. See also LOBELINE and CARDINAL FLOWER.
Hazard Codes:
T: Toxic
Risk Statements about Lobeline hydrochloride (CAS NO.134-63-4):
R23/25: Toxic by inhalation and if swallowed.
Safety Statements:
S45 In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

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