Reference

Control technology assessment of hazardous waste disposal operations in chemicals manufacturing: in-depth survey report of E

Control technology assessment of hazardous waste disposal operations in chemicals manufacturing: in-depth survey report of E. I. du Pont de Nemours and Company, Chambers Works Incinerator, Deepwater, New Jersey. Anastas, M. Y. (Eng. Control Technol. Branch, Natl. Inst. Occup. Saf. Health, Cincinnati, OH, USA). Report, CT-103-15B; Order No. PB84-242577, 44 pp. Avail. NTIS From: Gov. Rep. Announce. Index (U. S.) 1984, 84(25), 48 (English) 1984. DOCUMENT TYPE: Report CA Section: 59 (Air Pollution and Industrial Hygiene) Section cross-reference(s): 60 An in depth survey was conducted to assess control technol. of hazardous waste disposal operations at the Chem. Works incinerator. Area and breathing zone samples were analyzed for PhMe [108-88-3], o-chloronitrobenzene [88-73-3], and p-chloronitrobenzene [100-00-5]. All concns. were well below the relevant stds. Control and safety instrumentation consisted of an elec. operated interlock system that sensed process disturbances and shut down the furnace. Wastes were burned directly from tank trailers. Trailer vents were connected to a spot scrubbing system. The hose connections included a recirculation line that prevention the plugging of process and trailer discharge lines with dirt particles. Waste pumps were provided with explosion proof motors and double mech. seals. The company had programs for worker education and evaluation of on-the-job performance. Air monitoring of selected air contaminants was done routinely. Min. protective equipment required for working in the incinerator area included rubber gloves, hard hat, and butyl rubber covers for shoes. A state of the art hazard control systems is in place at the facility.

Influence of the culture time on DNA damage and repair in isolated rat hepatocytes exposed to nitrochlorobenzene derivatives

Influence of the culture time on DNA damage and repair in isolated rat hepatocytes exposed to nitrochlorobenzene derivatives. Cesarone, C. F.; Fugassa, E.; Gallo, G.; Voci, A.; Orunescu, M. (Fac. Sci., Univ. Genoa, Genoa 16132, Italy). Mutat. Res., 131(5-6), 215-22 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) The induction of DNA damage on 1.5 and 24 h cultured hepatocytes was tested after a 3 h exposure to 5 and 50 mM 1-chloro-4-nitrobenzene (I) [100-00-5], 1-chloro-2,4-dinitrobenzene [97-00-7], and 1-chloro-2,4,6-trinitrobenzene [88-88-0]. DNA repair synthesis, elicited by nitrochlorobenzene treatment, was also estd. 24 and 48 h after the withdrawal of the nitroaryl halides. DNA damage and repair were evaluated by detg. the DNA elution rate in alkali. A dose-related rate of DNA damage was obtained by exposure of 1.5 h-cultured hepatocytes to 5 and 50 mM nitrochlorobenzenes. DNA of 24-h-cultured cells was not affected by nitrochlorobenzene treatment. The data obtained by exposure to 5 mM Me methanesulfonate [66-27-3] and N-nitrosodimethylamine [62-75-9], direct and indirect methylating agents, suggest that 24 h-cultured liver cells are still able to transform nitrosodimethylamine but not nitrochlorobenzenes. Isolated hepatocytes maintain their capability of repairing the induced DNA damage when cultured for 24 and 48 h in fresh medium. The system offers an interesting model to investigate the perturbations related to the metab. of xenobiotics.