Detail of "100-33-4"

Reference

Effect of trypanocides on jugular concentration of Trypanosoma congolense in the West African dwarf sheep

Effect of trypanocides on jugular concentration of Trypanosoma congolense in the West African dwarf sheep. Kalu, Arunsi Ukairo (Dep. Vet. Livest. Stud., Niger. Inst. Trypanosomiasis Res., Vom, Nigeria). Vet. Parasitol., 13(4), 299-309 (English) 1983. CODEN: VPARDI. ISSN: 0304-4017. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of various trypanocides on parasitemia was investigated in sheep exptl.-infected with T. congolense strain 58/59. I.v. injection of Berenil [908-54-3] at the height of the first parasitemic wave increased jugular parasite concn. by 12 and 16 times at the 9th and 20th minute post-treatment, resp. With Pentamidine [100-33-4], max. counts were 5. 6798-24-9 and 3546-21-2 which are cas registry numbers are also used here.0-8.6 times zero-time concn. during the same periods. Peak effects of Samorin [6798-24-9], Novidium [602-52-8], and Ethidium [3546-21-2] were obsd. between the 60th and 90th minutes after drug administration and were 9.5, 6.3, and 3.5 times initial values, resp. Injection of trypanocides resulted in double peaks of parasitemia in which the second was usually higher than the first, except with Antrypol [129-46-4] and Germanin [129-46-4] which had not significant effect on parasitemia. The amplitude, but not the onset of the increase in parasitemia in sheep, was found to be related to the therapeutic efficacy of the trypanocides in the treatment of T. congolense infection in rats. Animals treated with the diamidines (Berenil and Pentamidine) exhibited apparent parasitol. cure of infection in sheep two to four days after treatment. However, administration of any of the drugs 1 wk after the first treatment resulted in flushing of cryptic trypanosomes into the jugular vein and counts as high as 7.63 ′ 103 mL-1 were obsd. within 10 min with Berenil. Thus, besides their therapeutic use, the diamidines may be of value in the parasitol. diagnosis of sub-patent trypanosomiasis due to T. congolense. .

Pentamidine, a new diabetogenic drug in laboratory rodents

Pentamidine, a new diabetogenic drug in laboratory rodents. Sal, P.; Boillot, D.; Boitard, C.; Debray-Sachs, M.; Reach, G.; Assan, R. (Vet. Sch. Nantes, Nantes, Fr.). Diabetologia, 25(5), 418-23 (English) 1983. CODEN: DBTGAJ. ISSN: 0012-186X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Mouse and rat islets were incubated with pentamidine [100-33-4] at 5 ′ 10-11-5 ′ 10-3M for 3-48 h. The B-cell responses to glucose + theophylline and to arginine were suppressed by pentamidine, while insulin [9004-10-8] release in nonstimulatory conditions was increased. These effects were concn.-dependent, time-dependent, and irreversible. They were significant for 5 ′ 10-7M pentamidine, which is a concn. relevant to therapeutic uses. These effects developed more slowly than the toxic effects of streptozotocin and alloxan at the same molar concn. 10-11-5 and 9004-10-8 are just another two chemicals used in this study. in vitro. 51Cr release and Trypan blue exclusion tests support the hypothesis that pentamidine produces islet cell necrosis. .