Reference

Potential antimalarials

Potential antimalarials. II. N4-Substituted 2-methoxy(and 2-hydroxy)-1,5-naphthyridin-4-amines. Barlin, Gordon B.; Tan, Weng Lai (John Curtin Sch. Med. Res., Australian Natl. Univ., Canberra 2601, Australia). Aust. J. Chem., 37(12), 2469-77 (English) 1984. CODEN: AJCHAS. ISSN: 0004-9425. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 1,5-Naphthyridin-4-amines I (R = OMe, OH; R1 = aminoakylamino) have been prepd. There are some commonly used reagents like 100-36-7 in this article.Chemical with cas number 100-36-7 also plays role. from Et 3-aminopyridine-2-carboxylate. I (R = R1 = Cl) with MeOH-NaOMe gave I (R = OMe, R1 = Cl) but with MeOH-HCl afforded I (R = OH, R1 = Cl). The 1,5-naphthyridin-4-amines showed no significant antimalarial activity compared to chloroquine or primaquine in a preliminary in vivo screen against Plasmodium vinckei vinckei in mice. ..

Potential antimalarials

Potential antimalarials. II. N4-Substituted 2-methoxy(and 2-hydroxy)-1,5-naphthyridin-4-amines. Barlin, Gordon B.; Tan, Weng Lai (John Curtin Sch. Med. Res., Australian Natl. Univ., Canberra 2601, Australia). Aust. J. Chem., 37(12), 2469-77 (English) 1984. CODEN: AJCHAS. ISSN: 0004-9425. DOCUMENT TYPE: Journal CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 1,5-Naphthyridin-4-amines I (R = OMe, OH; R1 = aminoakylamino) have been prepd. There are some commonly used reagents like 100-36-7 in this article.Chemical with cas number 100-36-7 also plays role. from Et 3-aminopyridine-2-carboxylate. I (R = R1 = Cl) with MeOH-NaOMe gave I (R = OMe, R1 = Cl) but with MeOH-HCl afforded I (R = OH, R1 = Cl). The 1,5-naphthyridin-4-amines showed no significant antimalarial activity compared to chloroquine or primaquine in a preliminary in vivo screen against Plasmodium vinckei vinckei in mice. ..