CAS No.100-37-8,Diethylaminoethanol Suppliers

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Basic Information

Molecular Structure:
CAS No.:	100-37-8
Name:	Diethylaminoethanol
Article Data:	52

Formula:	C₆H₁₅NO
Molecular Weight:	117.191
Synonyms:	2-diethylaminoethanol;(2-Hydroxyethyl)diethylamine;(Diethylamino)ethanol;2-(Diethylamino)ethanol;2-(Diethylamino)ethyl alcohol;2-(N,N-Diethylamino)ethanol;2-Hydroxytriethylamine;A 22 (amine);DEAE;DEEA;Diethyl(b-hydroxyethyl)amine;Diethylethanolamine;MKS;N,N-Diethyl(2-hydroxyethyl)amine;N,N-Diethyl-2-aminoethanol;N,N-Diethylethanolamine;N,N-Diethylmonoethanolamine;N-(2-Hydroxyethyl)diethylamine;NSC 8759;Pennad 150;b-(Diethylamino)ethanol;
EINECS:	202-845-2
Density:	0.884 g/cm³
Melting Point:	-70 °C
Boiling Point:	164.8 °C at 760 mmHg
Flash Point:	48.9 °C
Solubility:	soluble in water
Appearance:	clear to pale yellow liquid
Hazard Symbols:	C
Risk Codes:	10-20/21/22-34
Safety:	25-26-36/37/39-45
Transport Information:	UN 2686 8/PG 2
PSA:	23.47000
LogP:	0.32050

Synthetic route

: 75-21-8
oxirane

: 109-89-7
diethylamine

: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
With 3-amino-2-propanol at 70℃; under 4500.45 Torr; for 3h; Pressure; Temperature;	99.4%
With water
water at 85.84 - 94.84℃; under 1500.15 Torr; for 0.116667h; Heating / reflux;
at 76.84 - 112.84℃; under 1500.15 Torr; for 0.133333h; Heating / reflux;

: 109-89-7
diethylamine

: 540-51-2
2-bromoethanol

: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
In ethanol at 60℃; for 6h; Inert atmosphere;	96%

: 67-56-1
methanol

: 84115-05-9
2-(diethylamino)ethyl crotonate

A: 623-43-8
crotonic acid methyl ester

B: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
With toluene-4-sulfonic acid for 4h; Heating;	A 90% B 82%

...Expand

: 84115-05-9
2-(diethylamino)ethyl crotonate

A: 623-43-8
crotonic acid methyl ester

B: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
With methanol; toluene-4-sulfonic acid for 4h; Heating;	A 90% B 82%

: 1120-64-5
2-methyl-4,5-dihydro-1,3-oxazole

A: 110-73-6
2-(Ethylamino)ethanol

B: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
With platinum on carbon; hydrogen at 25℃; under 7500.75 Torr; for 16h;	A 60% B 19%

: 2002-24-6
2-amino-ethanol hydrochloride

: 75-03-6
ethyl iodide

: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
Stage #1: 2-amino-ethanol hydrochloride With potassium carbonate; ethanolamine In acetonitrile Heating; Stage #2: ethyl iodide for 6h; Heating;	7.8%

: 20570-43-8
carbonic acid ethyl ester-(2-diethylamino-ethyl ester)

A: 100-37-8
2-(Diethylamino)ethanol

B: 105-58-8
Diethyl carbonate

: 64-67-5
diethyl sulfate

: 141-43-5
ethanolamine

: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
With sodium hydroxide at 40℃;

: 107-21-1
ethylene glycol

: 121-44-8
triethylamine

: 100-37-8
2-(Diethylamino)ethanol

Conditions

Conditions	Yield
at 300℃;

: 109-89-7
diethylamine

: 107-07-3
2-chloro-ethanol

: 100-37-8
2-(Diethylamino)ethanol

Raw Materials

3739-10-4

2002-24-6

51-05-8

107-07-3

100-35-6

64-67-5

75-03-6

60-29-7

Downstream Products

479-50-5

Total:69 Page 1 of 2 1 2 Next>>

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Consensus Reports

Reported in EPA TSCA Inventory.

Standards and Recommendations

OSHA PEL: TWA 10 ppm (skin)
ACGIH TLV: TWA 10 ppm (skin)
DFG MAK: 5 ppm (24 mg/m³)
DOT Classification: 3; Label: Flammable Liquid

Analytical Methods

For occupational chemical analysis use NIOSH: Aminoethanol Compounds, 2007.

Specification

The CAS registry number of 2-Diethylaminoethanol is 100-37-8. Its EINECS registry number is 202-845-2. In addition, the molecular formula is C₆H₁₅NO. The systematic name is 2-(diethylamino)ethanol. What's more, it is used as pharmaceutical intermediates, softeners, emulsifiers and curing agents.

Physical properties about this chemical are: (1)ACD/LogP: 0.74; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 2; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 5; (9)Polar Surface Area: 23.47 Å²; (10)Index of Refraction: 1.443; (11)Molar Refractivity: 35.1 cm³; (12)Molar Volume: 132.3 cm³; (13)Polarizability: 13.91 ×10^-24cm³; (14)Surface Tension: 31.4 dyne/cm; (15)Density: 0.885 g/cm³; (16)Flash Point: 48.9 °C; (17)Enthalpy of Vaporization: 46.73 kJ/mol; (18)Boiling Point: 164.8 °C at 760 mmHg; (19)Vapour Pressure: 0.651 mmHg at 25°C.

Preparation of 2-Diethylaminoethanol: it can be prepared by diethylamine and epoxyethane at the certain temperature. The equation is as follows:

2-Diethylaminoethanol can be prepared by diethylamine and epoxyethane at the certain temperature

Uses of 2-Diethylaminoethanol: it can react with isocyanatomethyl-benzene to get N-Benzyl-carbaminsaeure-(2-diethylamino-ethylester). This reaction will need reagent triethylamine and solvent diethyl ether. The yield is about 74% at reaction temperature of 20-30 °C.

2-Diethylaminoethanol can react with isocyanatomethyl-benzene to get N-Benzyl-carbaminsaeure-(2-diethylamino-ethylester).

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable and can cause burns. And it is harmful by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection and avoid contact with eyes. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.).

You can still convert the following datas into molecular structure:
(1)SMILES: CCN(CC)CCO
(2)Std.InChI: InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3
(3)Std.InChIKey: BFSVOASYOCHEOV-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	skin	1mL/kg (1mL/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.
human	TCLo	inhalation	200ppm (200ppm)	GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 216, 1969.
mammal (species unspecified)	LDLo	unreported	1300mg/kg (1300mg/kg)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 216, 1969.
mouse	LC50	inhalation	5000mg/m³ (5000mg/m³)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 52, 1970.
mouse	LD50	intramuscular	416mg/kg (416mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
mouse	LD50	intraperitoneal	192mg/kg (192mg/kg)	BEHAVIORAL: ATAXIA	Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 249, 1948.
mouse	LD50	intravenous	188mg/kg (188mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
mouse	LD50	subcutaneous	650mg/kg (650mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Arzneimittel-Forschung. Drug Research. Vol. 9, Pg. 31, 1959.
rabbit	LD50	skin	1260uL/kg (1.26mL/kg)		Union Carbide Data Sheet. Vol. 6/11/1963,
rat	LCLo	inhalation	4500mg/m³/4H (4500mg/m³)	BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 14(11), Pg. 52, 1970.
rat	LD50	intraperitoneal	1220mg/kg (1220mg/kg)		Toxicology and Applied Pharmacology. Vol. 12, Pg. 486, 1968.
rat	LD50	oral	1300mg/kg (1300mg/kg)		Journal of Industrial Hygiene and Toxicology. Vol. 26, Pg. 269, 1944.