Reference

Cathodic reduction of 2- and 4-cyanopyridine at high-surface-area electrodes

Toomey, Joseph E., Jr.; Chaney, G. A.; Wilcox, M. (Reilly Tar Chem. Corp., Indianapolis, IN 46241, USA). Stud. Org. Chem. (Amsterdam), 30(Recent Adv. Electroorg. Synth.), 245-8 (English) 1987. CODEN: SOCHDQ. ISSN: 0165-3253. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) 4-Pyridinecarbonitrile was converted to 4-(aminomethyl)pyridine by two methods, in good yields. However, 2-(aminomethyl)pyridine was obtained from 2-pyridinecarbonitrile in a poor yield.

Pyridinylimidazole pharmaceuticals

Pyridinylimidazole pharmaceuticals. Lee, Thomas D. (USV Pharmaceutical Corp., USA). U.S. US 4510151 A 9 Apr 1985, 5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: A61K031-44. NCL: 514341000. APPLICATION: US 84-578918 10 Feb 1984. 2999-46-4 which is the cas registry number is also used here. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 1, 28 Pharmaceuticals useful for congestive heart failure and hypertension treatment contained pyridinylimidazoles, I, where R1 = OH, NH2, OMe, or OEt and R2 = H, halo, or OH. Thus, 15.4 g Et isocyanoacetate [2999-46-4] was treated with 14 g 4-cyanopyridine [100-48-1] in diglyme and NaOH to give 8.3 g Et 4(5)-(4-pyridinyl)imidazole-5(4)-carboxylate (II) [96860-21-8]. II.2HCl [96892-64-7] at 0.1-10 mg/kg i.v. and at 300 mg/kg intraduodenally increased myocardial contractile force and caused a moderate decrease in blood pressure in dogs. Oral compns. could also be used. .