Reference

Modification of the surface of porous polymer sorbents in a glow discharge plasma

Gil'man, A. B.; Zakharova, T. K.; Volkov, S. A.; Kolotyrkin, V. M.; Grigor'eva, G. A.; Sakodynskii, K. I.; Tunitskii, N. N. (Nauchno-Issled. Fiz.-Khim. Inst. im. Karpova, Moscow, USSR). Zh. Fiz. Khim., 53(10), 2621-4 (Russian) 1979. CODEN: ZFKHA9. ISSN: 0044-4537. DOCUMENT TYPE: Journal CA Section: 36 (Plastics Manufacture and Processing) By glow discharge treatment of Polysorb 1 [9003-70-7] sorbent in the presence of vapors of N-contg. org. compds. led to modification of its porous surface due as the result of formation of new functional groups on the sorbent surface. Such modification led to an increase in the retention time of polar substances. The sp. surface of the sorbent decreased from 224 to 147 m2/g on treatment in the presence of a-vinylpyridine (I) [100-69-6] and 2-(1,2-difluoro-2-chlorovinylpyridine) [395-02-8] and to 145 and 154 m2/g in the presence of N-methylpyrrolidone (II) [872-50-4] and m-fluorobenzoylamine [100-82-3], resp. The pore size of the sorbent increased from 20 to 75 ? in the presence of I. The highest retention time for acetonitrile, Me2CO and Et2O was obsd. for the sorbent treated with II.

Amino acid derivatives, their preparation and anticonvulsant pharmaceutical compositions containing them

Amino acid derivatives, their preparation and anticonvulsant pharmaceutical compositions containing them. Kohn, Harold L.; Watson, Darrell (Research Corp. , USA). Eur. Pat. Appl. EP 194464 A1 17 Sep 1986, 39 pp. DESIGNATED STATES: R: AT, BE, CH, DE, FR, GB, IT, LI, LU, NL, SE. (European Patent Organization) CODEN: EPXXDW. CLASS: ICM: C07C103-50. ICS: C07C103-76; C07C149-243; C07K005-04; A61K031-16; A61K037-02. APPLICATION: EP 86-101865 14 Feb 1986. PRIORITY: US 85-702195 15 Feb 1985. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) Section cross-reference(s): 1, 63 RNH(COCR2R3NH)nCOR1 [R, R1 = (un)substituted lower alkyl, aryl lower alkyl or Ph; R2, R3 = H, (un)substituted lower alkyl, aryl lower alkyl or Ph; n = 1-4], useful in the treatment of epilepsy and other central nervous system disorders, and as anticonvulsants, were prepd. Thus, 0. 106502-14-1 is also in the experiment.022 mol Ac2O was added to a soln. of 0.021 mol DL-alanine-N-benzylamine in CH2Cl2 and the resulting mixt. was stirred at room temp. for 3h to give 54% DL-AcNHCHMeCONHCH2Ph. The medium effctive dosages for some of the tested title compds. were comparable to those of phenytoin, mephenytoin, and phenacemide. .