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CAS No.: | 100-88-9 |
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Name: | Cyclamic acid |
Article Data: | 21 |
Molecular Structure: | |
Formula: | C6H13 N O3 S |
Molecular Weight: | 179.24 |
Synonyms: | Cyclohexanesulfamicacid (6CI,7CI,8CI);Sulfamic acid, cyclohexyl- (9CI);Cyclamate;Cyclamic acid;Cyclohexylamidosulfuric acid;Cyclohexylaminesulfonic acid;Cyclohexylsulfamicacid;Hexamic acid;N-Cyclohexylsulfamic acid;NSC 220327;Polycat 200; |
EINECS: | 202-898-1 |
Density: | 1.32g/cm3 |
Melting Point: | 165 - 170 C (Decomposes) |
Boiling Point: | °Cat760mmHg |
Flash Point: | °C |
Solubility: | Soluble SOLVENT |
Appearance: | white crystals |
Hazard Symbols: | UN NO. |
Safety: | Suspected human carcinogen producing bladder tumors. Poison by intravenous route. Mildly toxic by ingestion. When heated to decomposition it emits toxic fumes of SOx and NOx. |
Transport Information: | 25kgs |
PSA: | 74.78000 |
LogP: | 2.18320 |
Conditions | Yield |
---|---|
With chlorosulfonic acid In chloroform for 8h; Ambient temperature; | 72% |
With chlorosulphuric acid; chloroform | |
With chlorosulfonic acid | |
With chlorosulfonic acid In acetonitrile at 20℃; for 2h; |
Conditions | Yield |
---|---|
With sulfuric acid; sulfur trioxide |
Conditions | Yield |
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With sulfur dioxide; benzene |
Conditions | Yield |
---|---|
With sodium dithionite; water; sodium phosphate |
cyclohexylsulfamic acid
(R)-6-methylamino-2-methylheptene
Conditions | Yield |
---|---|
In ethanol at -20℃; Solvent; Temperature; | 100% |
Conditions | Yield |
---|---|
In methanol at 20℃; | 95.6% |
cyclohexylsulfamic acid
ziprazidone
Conditions | Yield |
---|---|
In ethanol; water at -15 - 80℃; | 95.2% |
N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′-(4-(2-methylpropyloxyl)phenylmethyl)carbamide
cyclohexylsulfamic acid
Conditions | Yield |
---|---|
In ethyl acetate at 20 - 42℃; for 5h; | 93.7% |
cyclohexylsulfamic acid
dasatanib
Conditions | Yield |
---|---|
In methanol at 70℃; | 93.4% |
Chemistry informtions about Cyclamic acid (100-88-9) is:
IUPAC Name: (2E)-2-hydroxyimino-1-phenylpropan-1-one ; -hydroxyimino-1-phenylpropan-1-one
Synonyms: Cyclohexanesulphamic acid ; cyclohexanesulphamicacid ; Cyclohexylamidosulfuric acid ; cyclohexylamidosulfuricacid ; Cyclohexylamidosulphuric acid ; cyclohexylamidosulphuricacid ; Cyclohexylaminesulfonic acid ; cyclohexylaminesulfonicacid
MF: C6H13NO3S
MW: 179.24
EINECS: 202-898-1
Melting Point: ~180 °C (dec.)
Density: 1.32 g/cm3
Following is the molecular structure of Cyclamic acid (100-88-9) is:
The sodium and calcium salts of Cyclamic acid (100-88-9) are used as artificial sweeteners under the name cyclamate.This Chemical is banned in the USA and other countries for use as a sweetener. In the UK it used to be banned, but now it is allowed.This is also sometimes considered to be a carcinogen.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
mouse | LD50 | intravenous | 180mg/kg (180mg/kg) | | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01774, |
mouse | LD50 | oral | 680mg/kg (680mg/kg) | Behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: respiratory stimulation gastrointestinal: changes in structure or function of salivary glands | National Technical Information Service. Vol. OTS0540890, |
rat | LD50 | intravenous | 4gm/kg (4000mg/kg) | | American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953. |
rat | LD50 | oral | 12gm/kg (12000mg/kg) | | American Journal of the Medical Sciences. Vol. 225, Pg. 551, 1953. |
Safety Statements:
S22: Do not breathe dust.
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: GV6950000