Reference

Protective effects of cyclodextrins on the hemolysis induced with imipramine in vitro

Protective effects of cyclodextrins on the hemolysis induced with imipramine in vitro.Some chemicals with cas registry numbers like 87980-41-4 and 7585-39-9 are also used. Uekama, Kaneto; Irie, Tetsumi; Otagiri, Masaki; Hoshino, Teruhiko; Yamada, Yoshitsugu; Ohtani, Yoshiro (Fac. Pharm. Sci., Kumamoto Univ., Kumamoto 862, Japan). Maku, 8(5), 315-21 (Japanese) 1983. CODEN: MAKUD9. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 22 a- [10016-20-3], b- [7585-39-9], And g-cyclodextrins [17465-86-0] protected human erythrocytes against imipramine (I) [50-49-7]-induced hemolysis. This protection was attributed to the formation of inclusion complexes between the cyclodextrins and I. The degree of protection afforded by each cyclodextrin against I-induced hemolysis was dependent on the stability of the I-cyclodextrin complexes, i.e. b-cyclodextrin-imipramine [87980-43-6] > g-cyclodextrin-imipramine [87980-42-5] > a-cyclodextrin-imipramine [87980-41-4]. The affinity of the I-cyclodextrin complexes for human erythrocytes was small when compared to that of free I. Thus, the protective effect of cyclodextrins appears to be due to the redn. in free I available for hemolysis and not due to a stabilization of the erythrocyte membrane. .

Effects of grinding on the physical and chemical properties of crystalline medicinals with microcrystalline cellulose

Effects of grinding on the physical and chemical properties of crystalline medicinals with microcrystalline cellulose. VI. The dispersed states of medicinal molecules in ground mixtures with a- or b-cyclodextrin. Nakai, Yoshinobu; Yamamoto, Keiji; Terada, Katsuhide; Akimoto, Katsuya (Fac. Pharm. Sci., Chiba Univ., Chiba 260, Japan). Chem. Pharm. Bull., 32(2), 685-91 (English) 1984. CODEN: CPBTAL. ISSN: 0009-2363.In this article, certain chemicals are used. Some of their cas registry numbers are 7585-39-9 and 12619-70-4 DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The mol. behavior of aspirin [50-78-2], benzoic acid, and p-hydroxybenzoic acid in ground mixts. with cyclodextrins was investigated by IR spectral anal. of the C:0 stretching region. With a-cyclodextrin [10016-20-3], a 1:1 inclusion complex is formed with p-hydroxybenzoic acid. H bonding occurred between the OH of a-cyclodextrin and C:O group of the acid. Similar results were obsd. with b-cyclodextrin [7585-39-9]. The formation of inclusion complexes was also confirmed by NMR spectra. Hydrolysis of aspirin in the presence of cyclodextrins followed 1st-order kinetics. The rate consts. showed no variations in the presences of a-cyclodextrin, although a deceleration effect was obsd. in the presence of b-cyclodextrin. Cyclodextrin [12619-70-4] had little inhibiting effect on the hydrolysis. .