Products Categories
CAS No.: | 10034-93-2 |
---|---|
Name: | Hydrazine sulfate |
Molecular Structure: | |
Formula: | H4N2.H2SO4 |
Molecular Weight: | 130.125 |
Synonyms: | Segidrin;HS;Hydrazine hydrogen sulfate;Sehydrin;Hydrazinium sulfate, Hydrazonium sulfate;Hydrazine,compounds,sulfate (1:1);Hydrazonium sulfate;Siran hydrazinu;Hydrazine monosulfate;Hydrazine, sulfate (1:1);Idrazina solfato;Hydrazine dihydrogen sulfate salt;Hydrazinium(2+) sulfate;Hydrazine sulfate (1:1);Hydrazinium sulfate;Hydrazine dihydrogen sulfate; |
EINECS: | 233-110-4 |
Density: | 1,37 g/cm3 |
Melting Point: | 254 °C(lit.) |
Boiling Point: | 330 °C at 760 mmHg |
Solubility: | Soluble in hot water |
Appearance: | colourless crystal or white powder |
Hazard Symbols: | T,N |
Risk Codes: | 45-23/24/25-43-50/53 |
Safety: | 53-45-60-61 |
Transport Information: | UN 2923 8/PG 3 |
PSA: | 135.02000 |
LogP: | 0.64740 |
Conditions | Yield |
---|---|
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4; | A n/a B 90% |
With sodium hydroxide In acetic acid byproducts: Na2CO3; redn. in presence of Zn dust than reflux with NaOH for 8-10 h; cooling; react. with H2SO4; | A n/a B 90% |
1,4-dihydro-1,2,4,5-tetrazine-3,6-dicarboxylic acid
A
hydrazinium sulfate
B
hydrazine
Conditions | Yield |
---|---|
With sulfuric acid In water byproducts: CO2; heating; isolation with benzaldehyde, distn. with steam; |
Conditions | Yield |
---|---|
With H2SO4; [MoCl(O)(1,2-bis(diphenylphosphino)ethane)]Cl In methanol other Radiation; γ-radiation of soln. of Mo-complex in MeOH and H2SO4 (under const. satn. of N2); |
sulfuric acid
hydrazinium sulfate
Conditions | Yield |
---|---|
With OC(NH)2(NH)2CO byproducts: CO2; dissolving paraunazine at 80°C in concd. H2SO4; 95-130°C, evaluation of CO2; | |
With OC(NH)2(NH)2CO byproducts: CO2; dissolving paraunazine at 80°C in concd. H2SO4; 95-130°C, evaluation of CO2; |
Conditions | Yield |
---|---|
With sodium hydroxide; chlorine In water addition of Cl2 to NaOH soln.; adding saturated NH3 soln. and gelatine; evapn. to half volume; addition of H2SO4 to cooled soln.; precipitn. with alcohol; | |
With NaClO; NaOH In water in presence of gelatine, addn. of H2SO4 in ice cooled soln.; recrystn. from boiling water; | 34-37 |
With NaOH; Cl2 In water addition of Cl2 to NaOH soln.; adding saturated NH3 soln. and gelatine; evapn. to half volume; addition of H2SO4 to cooled soln.; precipitn. with alcohol; | |
With sodium hydroxide; sodium hypochlorite In water in presence of gelatine, addn. of H2SO4 in ice cooled soln.; recrystn. from boiling water; | 34-37 |
Conditions | Yield |
---|---|
1:1 molar ratio of educs reacted as described by K. C. Patil, R. Soundararajan, and V. R. Pai Verneker, Proc. Indian Acad. Sci., Sect. A, 1978,87, 281; 1979, 88, 211; K. C. Patil, R. Soundrarajan, and V. R. Verneker, Inorg. Chem., 1979, 18, 1969 et. al; elem. anal.; |
monofluorourea
sulfuric acid
B
fluoroammonium ion
C
hydrazinium sulfate
Conditions | Yield |
---|---|
In not given ratio of decompn. products depends on the temp. and concn. of H2SO4; |
Conditions | Yield |
---|---|
at 302 °C dec. to give Mg(N2H4)SO4 and N2H6SO4, at 504 °Cproceed further endothermic dec.; |
Conditions | Yield |
---|---|
With NaOH; NaCl In water Kinetics; byproducts: NH3, N2O; hydrazine soln. contg. buffer and solid Fe complex mixed at 25.0°C, pH 6-10, ionic strength 0.1 M (NaCl); not isolated; monitored spectrophotometrically; | 95% |
hydrazinium sulfate
Conditions | Yield |
---|---|
In water at 60℃; for 1h; | 90% |
The Hydrazine sulfate (1:1) is an organic compound with the formula H4N2.H2SO4. The IUPAC name of this chemical is hydrazine; sulfuric acid. With the CAS registry number 10034-93-2, it is also named as Diamidogen sulfate. The product's categories are Pharmaceutical Intermediates; Inorganics; ACS GradeOrganic Building Blocks; Essential Chemicals; Hydrazines; Nitrogen Compounds; Routine Reagents; Organic Building Blocks; Analytical Reagents for General Use; E-L, Puriss p.a. ACS; Puriss p.a. ACS. Besides, it is colourless crystal or white powder, which should be stored in a closed dry and well-ventilated place.
Physical properties about Hydrazine sulfate (1:1) are: (1)ACD/LogP: -1.03; (2)ACD/LogD (pH 5.5): -5.53; (3)ACD/LogD (pH 7.4): -5.53; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)#H bond acceptors: 4; (7)#H bond donors: 2; (8)Polar Surface Area: 60.98 Å2; (9)Enthalpy of Vaporization: 62.94 kJ/mol; (10)Boiling Point: 330 °C at 760 mmHg; (11)Vapour Pressure: 3.35E-05 mmHg at 25°C.
Preparation: this chemical can be prepared by urea, sodium hypochlorite, caustic soda. This reaction will need reagent sulfuric acid, catalyst potassium permanganate.
Uses of Hydrazine sulfate (1:1): it is a chemical compound that has been used as an alternative medical treatment for the loss of appetite (anorexia) and weight loss (cachexia) which is often associated with cancer. It has never been approved as a mainstream drug, although it is approved for use in clinical trials by the U.S. Food and Drug Administration (FDA) and is marketed in the United States as a dietary supplement. It is also sold over the internet by websites that promote its use as a cancer therapy. It is used in palliative care for terminal cancer patients in Russia and other countries of the former Soviet Union.
When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed and very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell seek medical advice immediately (show the label where possible). Besides, this chemical may cause sensitisation by skin contact and may cause cancer. Please avoid exposure - obtain special instructions before use. When you are using it, avoid release to the environment. Refer to special instructions/safety data sheet. This material and its container must be disposed of as hazardous waste.
You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(O)O.NN
(2)InChI: InChI=1/H4N2.H2O4S/c1-2;1-5(2,3)4/h1-2H2;(H2,1,2,3,4)
(3)InChIKey: ZGCHATBSUIJLRL-UHFFFAOYAL
(4)Std. InChI: InChI=1S/H4N2.H2O4S/c1-2;1-5(2,3)4/h1-2H2;(H2,1,2,3,4)
(5)Std. InChIKey: ZGCHATBSUIJLRL-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | oral | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
human | TDLo | oral | 201mg/kg/8D (201mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Chemotherapy Reports, Part 1. Vol. 59, Pg. 1151, 1975. |
mammal (species unspecified) | LC | inhalation | > 6400ug/m3 (6.4mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. | |
mouse | LD50 | intraperitoneal | 152mg/kg (152mg/kg) | LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Archives of Environmental Health. Vol. 17, Pg. 315, 1968. |
mouse | LD50 | oral | 434mg/kg (434mg/kg) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 28(12), Pg. 56, 1984. | |
mouse | LD50 | subcutaneous | 455mg/kg (455mg/kg) | Acta Biologica et Medica Germanica. Vol. 21, Pg. 635, 1968. | |
rabbit | LDLo | oral | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935. | |
rat | LD50 | intraperitoneal | 230mg/kg (230mg/kg) | Russian Pharmacology and Toxicology Vol. 41, Pg. 74, 1978. | |
rat | LD50 | oral | 601mg/kg (601mg/kg) | "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972Vol. -, Pg. 15, 1972. |