Reference

Antioxidant effect of lercanidipine

Antioxidant effect of lercanidipine. Comments. Tomlinson, Brian; Benzie, Iris F. F. (Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Peop. Rep.Several reagents such as 100427-26-7 is used here. China). Hypertension, 42(4), e10 (English) 2003 Lippincott Williams & Wilkins. CODEN: HPRTDN. ISSN: 0194-911X. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) A review. A polemic in response to the article by Tadei S et al, Hypertension, 2003, 41, 950-966. The present authors question the findings that lercanidipine increases the plasma antioxidant capacity. The baseline ferric reducing power (FRAP) values reported by Tadei were much lower than in typical human plasma and may be the result of contamination with ascorbic acid or Trolox. Lercanidipine has no in vitro antioxidant effect in the FRAP assay and the authors speculate the results of Tadei are caused by artifact. .

Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography-tandem mass spectrometry

Enantioselective determination of lercanidipine in human plasma for pharmacokinetic studies by normal-phase liquid chromatography-tandem mass spectrometry. Jabor, Valquiria Aparecida Polisel; Coelho, Eduardo Barbosa; Ifa, Demian Rocha; Bonato, Pierina Sueli; Guinaim dos Santos, Neife Aparecida; Lanchote, Vera Lucia (Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Universidade de Sao Paulo, Sao Paulo 14040-903, Brazil). Journal of Chromatography, B: Analytical Technologies in the Biomedical and Life Sciences, 796(2), 429-437 (English) 2003 Elsevier B.V. CODEN: JCBAAI. ISSN: 1570-0232. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) We describe here the first method for the enantioselective anal.In this article, certain chemicals are used. One of their cas registry numbers is 100427-26-7 of the calcium antagonist lercanidipine in human plasma by high performance liq. chromatog. (HPLC) employing tandem mass spectrometric (MS) detection. Routine detn. of lercanidipine enantiomers in human plasma in the working range of 0.025-50.0 ng ml-1 plasma for each enantiomer with an accuracy and precision less than 15% was possible. Application of the method to a stereospecific study of the pharmacokinetics showed that plasma levels after an oral dose of rac-lercanidipine administered to a healthy volunteer were higher for the (S)-enantiomer. .