Detail of "1005-67-0"

Reference

Evaluation of morpholine, 3-morpholinone, and N-substituted morpholines in the rat hepatocyte primary culture/DNA repair test

Evaluation of morpholine, 3-morpholinone, and N-substituted morpholines in the rat hepatocyte primary culture/DNA repair test. Conaway, C. Clifford; Tong, Charles; Williams, Gary M. (Texaco Res. Cent., Beacon, NY 12508, USA). Mutat. Res., 136(2), 153-7 (English) 1984. CODEN: MUREAV. ISSN: 0027-5107. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Morpholine [110-91-8] and a series of morpholine derivs. were assayed for the potential to induce DNA repair in the rat hepatocyte primary culture/DNA repair assay. Morpholine did not induce DNA repair at dose concns. which were not toxic (0.0001-0.1 mg/mL). Two metabolites of morpholine, N-methylmorpholine oxide [7529-22-8] and N-hydroxymorpholine (I) [5765-63-9], also did not induce DNA repair at the nontoxic concns. tested (0.0001-10 and 0.0001-1 mg/mL, resp.). A putative metabolite of morpholine, 3-morpholinone [109-11-5], was inactive (0.001-10 mg/mL) and a polyurethane foam catalyst, N-butylmorpholine [1005-67-0] (0.0001-0.1 mg/mL) was also inactive. The chem. intermediate N-hydroxyethylmorpholine [622-40-2] induced DNA repair in the dose range 1-5 mg/mL. Thus genotoxicity of substituted morpholines is a function of the substituent moiety rather than morpholine itself.

N-Alkylmorpholines

N-Alkylmorpholines. (Toyo Soda Mfg. Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 59005174 A2 12 Jan 1984 Showa, 7 pp. (Japanese). (Japan). CODEN: JKXXAF. CLASS: IC: C07D295-02; B01J021-12; B01J023-06; B01J023-28; B01J023-34; B01J027-18. APPLICATION: JP 82-112572 1 Jul 1982. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) N-Alkylmorpholines I (R = Me, Et, Bu) were prepd. by vapor phase reaction of RN(CH2CH2OH)2 (II) in the presence of Al2O3 catalysts contg. 0.01-20 wt.% metal oxides (e.g., SiO2, B2O3, P2O5). Thus, a colloidal mixt. of 4000 g 10 wt. 1005-67-0 and 139-87-7 which are cas registry numbers of chemicals are mentioned. Al2O3 and 47 g 20 wt.% SiO2 was dried, crushed, and calcined 3 h at 600° in air to form a catalyst. Passing 5.95 g/h II (R = Et) (III) and 15.3 g/h H2O over 20 mL the catalyst at 280° gave, after 6 h, 87% I (R = Et) (IV) with 99.7% conversion of III and 87.3% selectivity for IV. .