Reference

The antischistosomal activity of substituted indoles

The antischistosomal activity of substituted indoles. Khan, M. (Dep. Med., Univ. Ottawa, Ottawa, ON K1H 8L6, Can.). J. Environ. Sci. Health, Part B, B18(6), 781-93 (English) 1983. CODEN: JPFCD2. ISSN: 0360-1234. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) 5-Bromoindole carboxylic acid [89252-96-0] and substituted indoles were administered parenterally to hamsters infected with an Egyptian strain of Schistosoma mansoni, to assess their antischistosomal activity. 87-48-9 and 3469-20-3 which are cas registry numbers of substances are two of reagents here. 5-Bromoindole (I) [10075-50-0] showed a significant hepatic shift in 59% of treated hamsters. It appears that modification of the indole nucleus may produce a series of antischistosomal agents. Structure-activity relations are discussed. .

p-p* Transition and the solvent effect on ultraviolet absorption spectra of substituted indoles

p-p* Transition and the solvent effect on ultraviolet absorption spectra of substituted indoles. Sanyal, Nitish K.; Tripathi, Sita Ram (Dep. Phys., Univ. Gorakhpur, Gorakhpur 273001, India). Acta Phys. Pol. A, A64(4), 487-93 (English) 1983. CODEN: ATPLB6. ISSN: 0587-4246. DOCUMENT TYPE: Journal CA Section: 22 (Physical Organic Chemistry) UV spectra of N- and 5-methyl-, 1,2-dimethyl-, 5-hydroxy-, 2,3-dihydro- and 5-bromoindoles were studied in polar and nonpolar solvents at 50,000-28,000 cm-1. 875-79-6 and 10075-50-0 are also in the experiment. The solvent and substituent effects are discussed for the p-p* electronic transition in these mols. Only 1 system in these derivs. (except 5-hydroxyindole) was obsd. distinctly at 37,000-33,000 cm-1. p-Electron delocalization over both rings was established. .