Detail of "10121-91-2"

Reference

Inhibition of pokeweed mitogen-induced B cell differentiation by compounds containing primary amine or hydrazine groups

Inhibition of pokeweed mitogen-induced B cell differentiation by compounds containing primary amine or hydrazine groups. De Boccardo, Grace; Drayer, D.; Rubin, A. L.; Novogrodsky, A.; Reidenberg, M. M.; Stenzel, K. H. (Med. Coll., Cornell Univ., New York, NY, USA). Clin. Exp. Immunol., 59(1), 69-76 (English) 1985. CODEN: CEXIAL. ISSN: 0009-9104. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 15 The effect of 2 drugs, which contain either an arom. amine or hydrazine moiety and are known to induce lupus like syndromes in man (procainamide [51-06-9] and hydralazine [86-54-4]) and an aliph. amine (dansylcadaverine [10121-91-2]), on pokeweed mitogen (PWM)-induced B cell prodn. of IgG (IgG). was studied. These compds. all inhibited IgG prodn. and generation of IgG plaque forming cells, whereas derivs. of them, without free amine groups, had little or no effect. The compds. inhibited differentiation of B cells to plasma cells, rather than prodn. and secretion of IgG. Mitogen free culture supernatants of peripheral blood mononuclear cells (PBM) activated by the oxidizing mitogen, neuraminidase and galactose oxidase (NAGO), prevented the inhibition of B cell maturation. Moreover, incubation of NAGO treated PBM with hydralazine prevented the prodn. of sol. factors capable of promoting B cell maturation in the presence of hydralazine. Apparently, procainamide, hydralazine and dansylcadaverine inhibit PWM-induced B cell maturation to plasma cells by an indirect mechanism, via inhibition of prodn. of lymphokines by helper cells. The primary amine or hydrazine group appears to be required for the inhibitory effect, since analogs of the inhibitory compds., without primary amine groups, are non-inhibitory.

Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus

Effects of lysosomotropic weak bases on infection of BHK-21 cells by Sindbis virus. Cassell, Sally; Edwards, Judy; Brown, Dennis T. (Cell Res. Inst., Univ. Texas, Austin, TX 78712, USA). J. Virol., 52(3), 857-64 (English) 1984. CODEN: JOVIAM. ISSN: 0022-538X. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of the lysosomotropic weak bases chloroquine [54-05-7], NH4Cl, and amantadine [768-94-5] as well as dansylcadaverine [10121-91-2] (an inhibitor of receptor-mediated endocytosis) on the replication of Sindbis virus in tissue-cultured cells was examd. Chloroquine had no effect on the expression of virus-induced homologous interference. None of these drugs significantly affected the ability of a complex of a cell and single virion to form an infectious center. Chloroquine and NH4Cl inhibited the synthesis of virus RNA in established infections when added early in infection. These drugs also inhibited the prodn. of progeny virions when added any time after infection. Thus, the antiviral activity of these agents may not be due to an ability to prevent transport of the virus genome into the cell cytoplasm.